SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. 2010 Dec 1;12(6):654-61... T Shimazu,MD Hirschey,L Hua,... - 《Cell Metabolism》 被引量: 429发表: 2010年 SIRT1 and SIRT3 Deacetylate Homologous Substrates: Ace...
ARTICLES Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Clinical Course and Description of Causal Mutations in Two Patients LUIGI BOUCHARD, MARIE-FRANCE ROBERT, DMITRIY VINAROV, CHARLES A. STANLEY, GEOFFREY N. THOMPSON, ANDREW MORRIS, JAMES V. LEONARD, PATTI QUANT, BETTY Y.L ....
One such effect is upregulation of endothelial nitric oxide synthase (e-NOS) which generally leads to vasorelaxation. However, changing the balance between localized NO and O2− fluxes can also lead to oxidant stress and cellular injury through formation of reactive secondary oxidants such as ...
Here, we show that cholesterol-lowering agents, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, protect against cerebral injury by a previously unidentified mechanism involving the selective up-regulation of endothelial NO synthase (eNOS). Prophylactic treatment with HMG-CoA reductase ...
Isolation of pig mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene promoter: characterization of a peroxisome proliferator-responsive element. Low expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase gene during development correlates with an unusually low hepatic keto...
Acetoacetyl-CoA thiolase and 3-hydroxy-3-methylglutaryl coenzyme synthase which comprise the 3-hydroxy-3-methylglutaryl-CoA-generating system(s) for hepatic cholesterogenesis and ketogenesis exhibit dual mitochondrial and cytoplasmic loc... KD Clinkenbeard,WD Reed,RA Mooney,... - 《Journal of Biologic...
本研究采取新生犊牛肝细胞原代培养方 法,检测外源性BHBA对HMGCS基因表达水平的 影响,进一步探讨BHBA对奶牛肝脏脂肪酸氧化 代谢途径的影响。 1材料与方法 1.1主要试剂 琼脂糖、Tris、蛋白胨、酵母提取物、TaqDNA BHBA对体外培养犊牛肝细胞HMGCS 基因表达的影响 ■李鹏 1 刘敏跃 2 龙淼 1 郭洋 1 王哲 3 何剑斌 1 ...
Genetic basis of mitochondrial HMG-CoA synthase deficiency Deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHMGS) is a recessive disorder of ketogenesis that has been previously diagnosed in tw... R Aledo,J Zschocke,Pié,... - 《Human Genetics》 被引量: 92发表: 2001年 加...