TUBB3 A gene on chromosome 16q24.3 that encodes a beta tubulin, which is a major constituent of microtubules. TUBB3 plays a key role in proper axon guidance and maintenance. Molecular pathology Defects of TUBB3 cause congenital fibrosis of extraocular muscles type 3A, and cortical dysplasia comp...
The most characterized outcomes of non-proteolytic substrates’ modifications by CUL3 are the changes in their intracellular localization (microtubules, kinetochores, chromatin, FAs) and in interactions with other factors or large protein complexes or assemblies. Future identification of the downstream ...
In addition to apoptosis, various pathways of regulated cell death, specifically regulated necrosis (termed necroptosis), have been described [23] that could contribute to tissue defects associated with the loss of primary cilia. In contrast to immunogenically relatively silent apoptotic cell death, ne...
Subunit : Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins. Interacts with the dystrophin protein DMD ...
7a). For example, axonal outgrowth and guidance to the proper target tissues require the coordination of cellular programs, including the coordination of actin filaments and microtubules, the dynamic cytoskeletal polymers, and “building blocks” that promote shape change and locomotion during the ...
the bundling of microtubules [88]. Phosphoglycerate kinase The quaternary structure of most glycolytic enzymes has been well conserved during evolution. Monomeric forms are unusual, and one enzyme that is invariably a monomer is phosphoglycerate kinase. In mammals, two different, but functionally ...
Abstract:Background: Tau is a microtubule associated protein that regulates the stability of microtubules and the microtubule-dependent axonal transport. Its hyperphosphorylated form is one of the hallmarks of Alzheimer’s disease and other tauopathies and the major component of the paired helical filame...
Mice and humans encode multiple α- and β-tubulin isotypes that heterodimerize and polymerize to form microtubules (MTs). Tubb3 encodes the only β-tubulin isoform constitutively expressed in all neurons and not in radial or mature glia, making anti-TUBB3 antibody (Tuj1) the classic neuronal ...
This regulates cargo sorting, membrane scission, and FEME carrier transport onto microtubules. In hippocampal neurons, this control is required for proper growth cone formation, axon elongation, and branching. Results Different cell types display various levels of FEME activity Some cell types display ...
4-HNE is known to disrupt microtubules, an essential component of fast axonal transport, by binding to microtubular associated protein (22, 23), and causes conformational changes in the structure of ␣-tubulin, a major component of microtubules (24). 4-HNE is cytotoxic to oligodendrocytes in...