3 types of microtubules- aster- polar- kinetochore aster position polesinteract with cell membrane polar extend to middle push centrosomes further apart kinetochore attach to kinetochorepull sisters apart prometaphase begins with absence of nuclear envelopeallows spindle microtubules access to chromosomesspin...
3 types of microtubules aster polar kinetochore aster microtubules important for positioning the spindle apparatus polar microtubules help to push the poles away from each other kinetochore microtubules attach to the kinetochore, which is bound to the centromere of each individual chromosome...
The most characterized outcomes of non-proteolytic substrates’ modifications by CUL3 are the changes in their intracellular localization (microtubules, kinetochores, chromatin, FAs) and in interactions with other factors or large protein complexes or assemblies. Future identification of the downstream ...
7a). For example, axonal outgrowth and guidance to the proper target tissues require the coordination of cellular programs, including the coordination of actin filaments and microtubules, the dynamic cytoskeletal polymers, and “building blocks” that promote shape change and locomotion during the ...
Both the β-actin mRNA and ZBP1 were found to be colocalized in transport granules along microtubules (Micheva et al. 1998; Bassell and Singer 2001; Eom et al. 2003). Recently kinesin was found to transport large multisubunit complexes of proteins and mRNA in dendrites (Kanai 2004). More...
Microtubules are dynamic polymers of α/β-tubulin. They regulate cell structure, cell division, cell migration, and intracellular transport. Howev
Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN and FYVE domain-containing protein 3 (RUFY3) exists as two alternative
Dynein is the main motor responsible for the movement and force toward the negative end of microtubules, which plays a key role during interphase and cytokinesis [67]; it consists of the heavy, light, intermediate, and light intermediate chains [68]. Partner of Inscuteable (Pins) is a modul...
This regulates cargo sorting, membrane scission, and FEME carrier transport onto microtubules. In hippocampal neurons, this control is required for proper growth cone formation, axon elongation, and branching. Results Different cell types display various levels of FEME activity Some cell types display ...
APC binds the plus-end of microtubules and stimulates microtubule assembly and bundling. Phosphorylation of APC by GSK3β decreases its interaction with microtubules, likely regulating the targeting of APC and its associated Par3 protein. Consistently, inhibition of GSK3β activity in neurons leads ...