((2S,4S)-4-(5-((E)-2-Bromovinyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,3-dioxolan-2-yl)methyl (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl) Propanoate (29
Conversion of the immunoextracted 11-dehydro-TXB2 into its 1-methyl ester-11-n-propylamide-9,12,15-tris-dimethyl-isopropylsilyl ether derivative was followed by gas chromatography—selected-ion monitoring. The mass spectrum of the 11-dehydro-TXB2 derivative was dominated by th...
An object of the invention is also the compound of formula 3, where X=H or CH3 and R5=a nucleophilic leaving group, such as F, Br, Cl, NO2,—NR3+, where R=alkyl, such as CH3, C2H5, R2=benzyl (Bn), methyl (Me), and R4=(S)-BOC-BMI: (S)-1-(tert-butoxycarbonyl)-2-tert...
〖合成方法〗Synthesis of intermediate monosaccharide (VI): The reaction of L-arabinose (I) with benzyl alcohol and HCl (gas) gives 1-O-benzyl-L-arabinose (II), which is treated with 2,2-dimethoxypropane (III) and TsOH to yield the 3,4-O-isopropylidene derivative (IV). The selective ac...
aryl carbamate (XXVIII). The reaction of (XXVIII) with OsO4 and NaIO4 in dioxane/water affords the indoline derivative (XXIX), which is treated with NaBH4 in EtOH to afford the 2-phenylethanol derivative (XXX). The reaction of (XXX) with Tbdms-Cl, TEA and DMAP provides the silyl ether...
化学名称(+)-4(S)-(3,4-Difluorophenyl)-N-[3-[4-(4-fluorophenyl)piperidin-1-yl]propyl]-5(S)-methyl-2-oxooxazolidine-3-carboxamide CAS登记号218450-16-9 关联CAS登记号218450-17-0 (racemic; HCl) 分子式C25H28F3N3O3 结构式 分子量475.51541 ...
(4‐(4‐(4‐Methylbenzyl)‐7H‐pyrrolo[2,3‐d]pyrimidin‐6‐yl)phenyl)methanol (39 e): The SEM intermediate 37 e (144 mg, 0.313 mmol) was treated as described in General Procedure B, but with addition of THF (1 mL) in the last hydrolysis step. Purification by silica...
6. A compound selected from the group consisting of: 4-[(2R)-2-({[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}methyl)-3,4-dihydro-2H-chromen-6-yl]benzoic acid. 7. A method of treating obesity comprising the step of administering to a patient in need thereof a pharmaceutically ef...
20070179175 Tetrahydronaphthyridine Derivative 2007-08-02 Lunn 514/300 20070160616 Methods of treating Alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof 2007-07-12 Rosenthal et al. 424/146.1 20070031416 Use of antibody 2007-02-08 Shoji et al. 424/146.1...
The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the