(2-acetylsulfanyl-ethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propionylamino]methyl]phenyl]-3-[2-[[2-(3-benzylureido)thiazole-4-carbonyl]amino]acetylamino]-succinamic acid; (S)—N-[4-[3-[3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxo-2,5-...
An object of the invention is also the compound of formula 3, where X=H or CH3 and R5=a nucleophilic leaving group, such as F, Br, Cl, NO2,—NR3+, where R=alkyl, such as CH3, C2H5, R2=benzyl (Bn), methyl (Me), and R4=(S)-BOC-BMI: (S)-1-(tert-butoxycarbonyl)-2-tert...
[16] Using 7H‐pyrrolo[2,3‐d]pyrimidine and the corresponding 2‐methyl derivative as a starting point, we used molecular modelling software to dock the core fragment onto the CSF1R kinase hinge region and subsequently appended simple fragments expected to complement the binding pocket (using ...
Benzyl protection of one alcohol group and oxidation of other alcohol group to the aldehyde of diol 227, and then Wittig reaction deliver compound 228. Protection of a 1,2 diol with TBDMS group, obtained via asymmetric dihydroxylation of compound 228, yielded an alcohol 229 as a mixture of ep...
To a solution of bromoacetophenone derivative BB1 (3.06 g, 13 mmol) in absolute EtOH (50 mL) was added 1-benzoylpiperazine (2.50 g, 13 mmol) followed by diisopropylethylamine (2.30 mL, 13 mmol). The dark red reaction mixture was heated to 50° C. for 10 min, stirred at room temp...
6. A compound selected from the group consisting of: 4-[(2R)-2-({[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}methyl)-3,4-dihydro-2H-chromen-6-yl]benzoic acid. 7. A method of treating obesity comprising the step of administering to a patient in need thereof a pharmaceutically ef...
Description: 3-Acetylindole is a derivative of an indole. The substitution of indole in position 3 with aldehydes and with alkyl groups cause only minor changes in the molecular geometry, however, substantially larger alterations are found in the charge distribution and in the vibrational force cons...
Description: 3BDO, a butyrolactone derivative, could target FKBP1A and activate the mTOR signaling pathway. It inhibits autophagy in HUVECs. Name: 3BDOCAS#: 890405-51-3Chemical Formula: C18H19NO6Exact Mass: 345.1212Molecular Weight: 345.351Elemental Analysis: C, 62.60; H, 5.55; N, 4.06; O...
Description: 3-oxo-C5-HSL is a chain-shortened derivative of the bacterial quorum sensing signaling molecule N-3-oxo-octanoyl-L-homoserine lactone. It inhibits binding of the autoinducer N-3-oxo-hexanoyl homoserine lactone to E. coli containing the transcription factor LuxR. It acts as an autoi...
Description: 3-Aminotyrosine dihydrochloride is a Tyrosine derivative, being a useful probe to study the role of redox active tyrosines in enzymes. Name: 3-Aminotyrosine dihydrochlorideCAS#: 23279-22-3 (HCl)Chemical Formula: C9H14Cl2N2O3Exact Mass: 268.0381Molecular Weight: 269.122Elemental Analysis...