Alzheimer disease (AD) is the most common neurodegenerative disorder and constitutes ∼60–80% of all dementia (1, 2, 3). Age is the most common predictor, with 1 in 5 people aged >80 y and 1 in 3 people >90 y
Abstract:In older age, frailty is a detrimental transitional status of the aging process featuring an increased susceptibility to stressors defined by a clinical reduction of homoeostatic reserves. Multidimensional frailty phenotypes have been associated with all-cause dementia, mild cognitive impairment (...
Alzheimer’s disease (AD) is a globally prevalent form of dementia that impacts diverse populations and is characterized by progressive neurodegeneration and impairments in executive memory. Although the exact mechanisms underlying AD pathogenesis remain unclear, it is commonly accepted that the aggregation...
RT-qPCR and Western blot showed an upregulation of COL4A1 mRNA (10.6-fold increase; 95% CI, 1.4-fold to 17.1-fold increase) and protein levels (2.8-fold increase; 95% CI, 2.1-fold to 3.5-fold increase) in patient vs control group fibroblasts. Long-read RNA sequencing data showed that...
The increase in the rate of obesity globally is linked to the consumption of western diet, rich in simple sugars and saturated fat. While the research in MetS has generally remained in the domain of peripheral tissues, the effects of MetS in the CNS is also being recognized. MetS has ...
This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...Latest News FDA Grants Fast Track Designation to VERVE-102 Gene Therapy ...
Higher heart rates have been reported to be associated with an increased risk of dementia and accelerated rates of cognitive decline in the general elderly population, which can affect the quality of life in older adults [44]. Our find- ings found that high heart rate is an important risk ...
Therefore, we measured the AMPK alpha Thr172 phosphorylation in the brain of ZDF rats that were treated with 10 mg/kg Rosi, 1 mg/kg, and 10 mg/kg of CB3. As expected, Rosi-treated animals showed almost a two-fold increase in AMPK activation (Fig. 4A). Surprisingly, AMPK was equally...
building on externally benchmarked best in class collection practices • Stretching performance commitments on delivering affordability and serving customers in vulnerable circumstances: Moving the industry frontier with fivefold increase in the number of customers supported through Priority Services between 20...
The increase in the rate of obesity globally is linked to the consumption of western diet, rich in simple sugars and saturated fat. While the research in MetS has generally remained in the domain of peripheral tissues, the effects of MetS in the CNS is also being recognized. MetS has ...