A Diagram of human OTUD3, showing ovarian tumor (OTU) and ubiquitin-associated (UBA) domains, and active site (Cys76) directly involved in catalysis. B Crystal structure of the OTUD3 OTU domain. A cartoon representation is shown. The S1 Ub-binding site, Cys76, N termini, and C ...
The SH3 domains of syndapin and endophilin bind the PXXP motifs called Site 2 and 3 (Pro-786–Pro-793) at the N-terminal end of the proline-rich domain, whereas the amphiphysin SH3 binds Site 9 (Pro-833–Pro-836) toward the C-terminal end. In some proteins, SH3/peptide ...
Transposons are diverse mobile genetic elements that play the critical role as genome architects in all domains of life. Tn3 is a widespread family and among the first identified bacterial transposons famed for their contribution to the dissemination of antibiotic resistance. Transposition within this ...
Indeed, S-SCAM Tg mice that overexpress S-SCAM under the forebrain-specific Ca2+-dependent protein kinase II a (CaMKIIα) promoter showed a remarkably wide array of SCZ-related behavioral endophenotypes modeling all three domains (positive, negative, and cognitive) of SCZ symptoms14. Notably, ...
PDZ domains are abundant interaction hubs found in a number of different proteins and they exhibit characteristic differences in their structure and ligand specificity. Their internal dynamics have been proposed to contribute to their biological activity via changes in conformational entropy upon ligand bin...
Nodes per Socket (NPS) = 2 L3 as NUMA = Disabled NUMA domains within VM OS = 4 C-states = Enabled As a result, the server boots with 4 NUMA domains (2 per socket). Each domain is 32 cores in size. Each NUMA has direct access to 4 channels of physical DRAM operating at 3,200...
D3 helps you bring data to life using SVG, Canvas and HTML. D3 combines powerful visualization and interaction techniques with a data-driven approach to DOM manipulation, giving you the full capabilities of modern browsers and the freedom to design the right visual interface for your data. ...
The N protein partitioned into SGs through liquid-liquid phase separation with G3BP, and blocked the interaction of G3BP1 with other SG-related proteins. Moreover, the N protein domains important for phase separation with G3BP and SG disassembly were required for SARS-CoV-2 viral production....
977eb1d Update flakes, add some quality of life improvements (juanfont#1346) 1e7d7e5 Update go sha for flake 2ae882d Update go version a9da7c8 Update go.mod 5d3c027 Update golines fc502e1 Update golines and fix go mod checksum 3a3fc0a Update headscale checksum 5514a86 Update headsc...
In the structure of SIN3L, each Sin3 isoform (Pst1 and Pst3) interacts with one histone deacetylase Clr6, and one WD40-containing protein Prw1, forming two lobes. These two lobes are bridged by two vertical coiled-coil domains from Sds3/Dep1 and Rxt2/Png2, respectively. In the ...