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The known target of this checkpoint is the Cdc25 phosphatase, which needs to be inhibited to maintain the inhibitory phosphorylation of Cdk2 and block initiation of DNA replication35,36. Our data show that cyclin E conjugation with SUMO2/3 is independent from the kinase activity of Cdk2, ...
Cell Cycle ProteinsSubstrate SpecificityPhosphorylationReplication OriginDNA ReplicationS PhaseProtein-Serine-Threonine KinasesThe initiation of eukaryotic DNA replication is regulated by three protein kinase classes: cyclin-dependent kinases (CDK), Dbf4-dependent kinase (DDK) and the DNA damage checkpoint ...
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的调控机制的研究进展 做一综述. 关键词:CDK3;细胞周期;细胞周期素 中图分类号:Q555.7文献标识码:A AdvancesonResearchofCyclin—dependentKinases3HUANGDa— mao,MOLi,TANGFa—qing(XiangyaHospital, CentralSouthUniversity,Changsha410008,Hunan) Abstract:Cyclin— dependentkinases(CDKs)arethecoreofcellcycleregulation...
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