对小鼠进行行为学和电生理等研究,证实了(2R,6R)-HNK的抗抑郁作用。它的抑制效果有别于NMDA受体的抑制作用,而与AMPARs(α-氨基-3-羟基-5-甲基-4- 异恶唑丙酸受体)的激活有关。同时,研究结果证明,(2R,6R)-HNK不会造成氯胺酮相关的副作用。在...
中文名2R-6R-HNK 英文名2R-6R-HNK 中文别名 英文别名(2R,6R) 6-hydroxynorketamine;(2R,6R)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-one;cis-6-Hydroxy-norketamine; SMILESC1CC(C(=O)C(C1)(C2=CC=CC=C2Cl)N)O 化学名称
摘要：【目的】 初步探究鞘内注射2R， 6R-羟化去甲氯胺酮（2R， 6R-HNK）对慢性神经病理性疼痛（CNP）的镇痛作用及其机制。【方法】 采用坐骨神经选择性损伤（SNI）诱导的CNP模型。将雌性小鼠随机分不同组：假手术或SNI术后3 周或术前30 min/1 d给予溶剂、2R， 6R-HNK、S-ketamine（10 mg/kg腹腔注射...
动物实验显示,羟基氯胺酮的2R,6R异构体((2R,6R)-hydroxynorketamine,(2R,6R)-HNK),是氯胺酮的主要代谢产物.其具有与氯胺酮类似的快速抗抑郁的作用,而不伴有成瘾,致幻等副作用.但(2R,6R)-HNK并不能拮抗NMDA.提示氯胺酮抗抑郁作用的机制可能不是通过拮抗NMDA受体发挥作用的.研究中发现(2R,6R)-HNK在抗抑郁的...
英文名称: 2R-6R-HNK 分子式: C12H14ClNO2 纯度: 98 % 产地: 国产 品牌: 上海瀚香 货号: BCP1772400984 Product Name:2R-6R-HNKCAS No.:Purity:98%Formula:C12H14ClNO2详细产品说明和图谱,请联系邮箱:amber@biochempartner.net 现货促销,库存变动请咨询客服,订购优惠有礼.公司介绍:上海瀚香于08...
别名(2R,6R)6-羟基去甲氯胺酮 英文别名UNII-HB1X671CEU | HB1X671CEU | (2R,6R)HNK | (2R,6R)-HNK | HB3B4A37KE | Hydroxynorketamine (R,R;S,S) | HYDROXYNORKETAMINE, (2R,6R) | Hydroxynorketamine, (2R,6R)- | Cyclohexanone, 2-amino-2-(2-chlorophenyl)-6-hydroxy-, (2R,6R)-...
(2R,6R)-HNK’s mechanism of action however is unclear. The main goals of this study were to perform an in-depth pharmacological characterization of (2R,6R)-HNK at known ketamine targets, to use target deconvolution approaches to discover novel proteins that bind to (2R,6R)-HNK, and to...
Modulation of AMPA receptors (AMPARs) in the hippocampus and prefrontal cortex is suggested to mediate the antidepressant action of ketamine and of one of its metabolites (2R,6R)-hydroxynorketamine ((2R,6R)-HNK). We have examined whether ketamine and (2R,6R)-HNK affect glutamatergic ...
Ketamine and its metabolite (2R,6R)-hydroxynorketamine (HNK) have emerged as promising rapid-acting antidepressants. However, their mechanism of action remains unknown. In this study, we first described the anxious and depression-prone inbred mouse strain, DBA/2J, as an animal model to assess ...
Ketamine is an anesthetic, analgesic, and antidepressant whose secondary metabolite (2R,6R)-hydroxynorketamine (HNK) has N-methyl-d-aspartate-receptor-independent antidepressant activity in a rodent model. In humans, naltrexone attenuates its antidepressant effect, consistent with opioid pathway ...