The present invention relates to novel 2H-indazoles of the general formula (I), methods for the preparation thereof and the use thereof for the production of pharmaceutical agents for the treatment of diseases and indications which are linked with the EP 2 -receptor.Nico Bräuer...
A CuO nano catalysed one-pot synthesis of 2H-indazoles has been devised from easily accessible starting materials viz. 2-bromobenzaldehydes, primary amines and sodium azide under ligand free conditions. The nano CuO catalyst played an important role during the formation of the intermolecular C-N ...
Various cell‐based bioassay studies demonstrated that 2H‐indazoles inhibit the growth of cancer cells, typically through induction of apoptosis in a dose‐dependent manner. Moreover, 2H‐indazoles tested in the MDA‐MB‐468 cell line were capable of inhibiting cancer cell migration and invasion....
1H-Indazoles have benzenoid properties (are aromatic in nature), while 2-substituted 2H-indazoles have ortho-quinoid character [31], [32]. 3H-Indazoles lack heteroaromatic character and are very rare [33]. There is some evidence regarding the influence of the tautomeric equilibrium in indazole...
Among various catalysts, covalently anchored Cu(acac)2 onto amine functionalized silica/starch composite [ASS-Cu(acac)2] was found to be the most active and recyclable catalyst for the one-pot thioetherification and one-pot three component synthesis of 2H-indazoles via consecutive C–N and N–...
It is known that certain kinds of 3-chlorotetrahydroindazoles are effective as herbicides. For instance, the herbicidal use of 3-chloro-2-(2,4-dichloro-5-methoxyphenyl-4,5,6,7-tetrahydro-2H-indazole is disclosed in U.S. Pat. No. 4,059,434. However, the herbicidal effect of this compo...
2,3-dimethyl-6-nitro-2H-indazole CAS NO: 444731-73-1 分子量: 191.1867 EC NO: 暂无数据 规格: 暂无数据 包装: 暂无数据 结构式: 立即询盘1917070623518270595572 产品介绍 暂无产品详细介绍 品名:2,3-二甲基-6-硝基吲唑 用途:暂无数据 别名暂无数据 ...
2,3-diaryl-5,6-ethylenedioxy-2H-indazoles4,5-ethylenedioxy-2-phenylazobenzhydrolsA letter to the editor which discusses the results of a study that synthesizes 2H-indazoles is presented.doi:10.1007/s10593-008-0020-xS. S. MochalovM. I. Khasanov...
patent summary: "2h-indazoles as ep2 receptor antagonists". The present invention relates to novel 2h-indazoles of the general formula (I), methods for their preparation, and the use thereof for the production of pharmaceutical agents for the treatment of diseases and indications which are ...
The method is readily extended to the coupling reaction between azobenzenes and trifluoroacetaldehyde. This transformation efficiently produces a range of C3-unsubstituted and C3-trifluoromethylated (2H)-indazoles, which are important targets in the development of novel bioactive compounds. Excellent ...