To clarify the effect of the leucine substitution at position 118 in CYP2A6.25, this variant, wild type CYP2A6 and three additional variants consisting of artificial mutations at the substrate binding site (position 481) suggested by earlier reports using random mutagenesis studies [CYP2A6.1, CYP...
Hydroxyflavanone was metabolized by CYP2A6.25, but was not metabolized by wild-type CYP2A6.1. These results indicate that CYP2A6.25 possessed new substrate specificity toward flavonoids. Copyright (c) 2012 John Wiley & Sons, Ltd. 展开
THE STRUCTURE OF A SUBSTRATE COMPLEX OF MAMMALIAN CYTOCHROME P450 2C 5 AT 2.3A RESOLUTION : EVIDENCE FOR MULTIPLE SUBSTRATE BINDING MODES The structure of rabbit microsomal cytochrome P450 2C5/3LVdH complexed with a substrate,4-methyl-N-methly-n-(2-phenyl-2H-pyrazol-3-yl) benzenesulfonamide (...
(+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) was oxidized by human liver microsomes to produce the S-oxide as a sole metabolite. Indirect evidence suggested that the S-oxidation was catalyzed by cytochrome P450 (CYP). Eadie-Hofstee plots showed biphasic patt...
Solder the capacitor on the test substrate shown in Fig.3. of Termination should occur. Holding Time : 10+/-1s Applied Direction : In parallel with the test substrate and vertical with the capacitor side. Specification ■ Specifications and Test Methods No Item Test Method (Ref. Standard...
(CHX), a protein synthesis inhibitor, resulted in increased half-life of the CYP2A6 compared to cells treated only with CHX. Collectively, the observations indicate that the CYP2A6 may function as human %26quot;Bilirubin Oxidase%26quot; where bilirubin is potentially a substrate and a regulator ...
Solder the capacitor on the test substrate shown in Fig.3. of Termination should occur. Holding Time : 10+/-1s Applied Direction : In parallel with the test substrate and vertical with the capacitor side. Specification ■ Specifications and Test Methods No Item Test Method (Ref. Standard...
(+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes. 来自 Elsevier 喜欢 0 阅读量: 38 作者:K.-I. Nunoya,Y Yokoi,K Kimura,T Kodama,T Kamataki ...
Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase. 仅用于科研。不用于诊断过程。未经明确授权不得转售。相关产品 蛋白质免疫印迹 Secondary Antibodies 同型对照 WB...
transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase...