approximately 30% of epileptic patients have medically refractory seizures; other limitations in most traditional ASMs include poor tolerability and drug-drug interactions. Therefore, there is an urgent need to develop alternative ASMs
As with other types of interferon-α, interferon-α-2a produces an influenza-like syndrome, consisting of fever, chills, myalgia, headache, arthralgia and sweating within 4 to 8 hours of administration, although tolerance to many of these effects tends to develop during long term therapy. Long ...
These complexes in human, in addition to facilitation of gene transcription via histone acetylation activity, have also been shown to have additional functions such as acetylation of non-histone substrates and DNA damage response. Drosophila KAT2 complexes, dSAGA and ATAC, are also very similar in...
Signal transduction via activation of the ERK and AKT pathways exacerbates chondrocyte-mediated pro-catabolic activities during the progression of TMJ degen- erative remodelling. Inhibition of α2A-adrenoreceptor signal thus offers a novel therapeutic target for inhibition/ reversal of degenerative ...
The disease can be inherited via an autosomal recessive (ar), autosomal dominant (ad) or X-linked recessive mode or may occur in isolation; in fact, more than half of the cases in Japan are isolated cases.16 To date, 63 causative genes and 7 loci have been found to be associated with...
Dreyer B, Brox V, Tranebjærg L, Rosenberg T, Sadeghi AM, Möller C, Nilssen O. Spectrum of USH2A mutations in Scandinavian patients with Usher syndrome type II. Hum Mutat. 2008;29(3):451. Zupan A, Fakin A, Battelino S, Jarc-Vidmar M, Hawlina M, Bonnet C, Petit C, Glava...
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RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein Author links open overlay panelPeter A. Friedman 1 2, W. Bruce Sneddon 1, Tatyana Mamonova 1, Carolina Montanez-Miranda 3, Suneela Ramineni 3, Nicholas H. Harbin ...
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