The KMT2A rearrangement stratifies them to receive higher risk therapy with MRD response guiding furt treatment decisions, including the recommendation for HSCT in first complete remission in some protocols. The
We further clarified whether the increased surface GluN2A during cLTP was transported via the canonical or the non-canonical pathway. We assessed whether the surface increase of the GluN2A-containing NMDAR de- pended on microtubules and/or actin, since in canonical trafficking, the transport of ...
Introduction Acute Myeloid Leukaemia (AML) is a highly heterogeneous malignancy characterised by impairment of myeloid progenitor cell differentiation, leading to their clonal expansion and, ultimately, bone marrow failure.1Despite advances in the development of targeted therapies for AML, current treatments...
Alpha-2AARs are widely expressed and participate in a broad spectrum of physiologic functions including metabolic, cardiac, vascular, and central and peripheral nervous systems, via pre-synaptic and post-synaptic mechanisms. At peripheral sites, alpha-2AARs act to inhibit insulin secretion by pancreati...
刘强(中山大学孙逸仙纪念医院):Dynamic ctDNA tracking stratifies individual relapse risk and facilitates precision treatment for early TNBC 动态ctDNA监测可分层评估个体复发风险,并助力早期三阴性乳腺癌(TNBC)的精准治疗 江一舟(复旦大学附属肿瘤医院):Molecular Subtyping and Precision Treat...
[43] Zhao J, Li H, Zhao S, et al. Epigenetic silencing of miR-144/451a cluster contributes to HCC progression via paracrine HGF/MIF-mediated TAM remodeling[J]. Mol Cancer, 2021, 20(1):46. [44] Liu J, Zhao H, Hu...
purer feelings; you desire to recommence your life,and to spend what remains to you of days in a way more worthy of an immortal being.To attain this end,are you justified in overleaping an obstacle of custom-a mere conventional impediment which neither your conscience sanctifies nor your ...