Shaul . (2011) 27-Hydroxycholesterol: the first identified endogenous SERM. Trends in Endocrinology & Metabolism 22 , 130-135 Online publication date: 1-Apr-2011. /Umetani, M., Shaul, P.W., 2011. 27-Hydroxycholesterol: the first identified endoge- nous SERM. Trends Endocrin. Metab. 22,...
hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload. 相关产品:Natural Product Library Plus|Bioactive Compound Library Plus|Metabolism/Protease Compound Library|Natural Product Library|Anti-Cancer Compound Library|Human Endogenous Metabolite Compound Library...
Cell MetabolismUmetani M, Ghosh P, Ishikawa T, Umetani J, Ahmed M, Mineo C, et al. The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. Cell Metab 2014;20:172-82....
Thus, the prognosis for ER+ breast cancer is predicted by processes in the tumor that govern 27HC metabolism. 27HC Target Genes Promote ER+ Breast Cancer Growth Now knowing that diminished CYP7B1 expression enhances ER+ breast cancer cell proliferation, and that in parallel it adversely impacts...
ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-β (Aβ) metabolism, is a major genetic risk determinant for Alzheimer's Disease (AD) and drives its pathogenesis via Aβ-dependent and -independent pathways. C/EBPβ, a proinflammatory cytokines-activated transcription factor,...
26-Hydroxycholesterol : synthesis , metabolism , and biologic activities Cholest-5-ene-3&26-diol (26-hydroxycholesterol) is synthesized by a mitochondrial P-450 enzyme that appears to be widely distributed in tissues. Together w... '. NormanB.Javitt 被引量: 0发表: 2002年 ...
The interaction between metabolism, cancer and cardiovascular disease, connected by 27-hydroxycholesterol Oxysterols are metabolites of cholesterol that are produced in liver and other peripheral tissues as a means to eliminate cholesterol to bile acid. Recent ... WR Lee,T Ishikawa,M Umetani - 《Cl...
Wang, L.; Yu, H.; Hao, L.; Ju, M.; Feng, W.; Xiao, R. The Interaction Effect of 27-Hydroxycholesterol Metabolism Disorder and CYP27A1 Single Nucleotide Polymorphisms in Mild Cognitive Impairment: Evidence from a Case-Control Study.Mol. Nutr. Food Res.2023,67, e2200576. [Google Schol...
The above results suggest that 25-OH-cholesterol and CDC acid have different effects on lipid metabolism in Hep G2 cells. The mRNA levels of apo E increased in cells preincubated with 25-OH-cholesterol and CDC acid, which suggested that the increase in apo E secretion is at least partly ...
Levels of 27OHChol increase when cholesterol metabolism is disrupted, and the resulting inflammatory responses can contribute to the development and complications of metabolic syndrome, including obesity, insulin resistance, and cardiovascular diseases. Since 27OHChol can induce chronic immune response by ...