Further, the use of a small molecular weight inhibitor of the 26S proteasome via a non-covalent type inhibition is contemplated for use as a means to treat NF -kB mediated diseases, including but not limited to multiple myeloma and rheumatoid arthritis.doi:WO2010099445 A2TEPE, JetzeLANSDELL, TheresaKARIN, MichaelWO
surface (Cook et al., 1992; Trempe et al., 2010) and a dynamic ensemble of extended structures that can adopt a wide range of inter-ubiquitin orientations, but with constraint at the linker region where non-covalent interactions are formed between ligated ubiquitin moieties (Lu et al., ...
Regulatory subunit interactions of the 26S proteasome, a complex problem. Trends Biochem. Sci. 25, 83–88 (2000). CAS PubMed Google Scholar Wei, N. et al. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr. Biol. 8,...
Moreover, E3 confers the high specificity of the UPS; it regulates the recognition process by which proteins are tagged by Ub molecules to be degraded by the proteasomes. This specificity is attributed to the ability of the E3 enzyme to undertake various physical interactions with protein ...
The 26S proteasome is the most complex ATP-dependent protease machinery, of ~2.5 MDa mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated proteins and plays fundamentally indispensable roles in regulating almost all
Further, the use of a small molecular weight inhibitor of the 26S proteasome via a non-covalent type inhibition is contemplated for use as a means to treat NF -kB mediated diseases, including but not limited to multiple myeloma and rheumatoid arthritis.TEPE, JETZE...
The specificity of the ubiquitin (Ub) isopeptidase in the PA700 regulatory complex of the bovine 26 S proteasome was investigated. Disassembly of poly-Ub by this enzyme is restricted to the distal-end Ub of the substrate, i.e. the Ub farthest from the site of protein attachment in poly-...
surface (Cook et al., 1992; Trempe et al., 2010) and a dynamic ensemble of extended structures that can adopt a wide range of inter-ubiquitin orientations, but with constraint at the linker region where non-covalent interactions are formed between ligated ubiquitin moieties (Lu et al., ...
26S Proteasome Non-ATPase Regulatory Subunits 1 (PSMD1) and 3 (PSMD3) as Putative Targets for Cancer Prognosis and Therapy. Cells. 2021; 10(9):2390. https://doi.org/10.3390/cells10092390 Chicago/Turabian Style Rubio, Andres J., Alfonso E. Bencomo-Alvarez, James E. Young, Vanessa V....
26S Proteasome Non-ATPase Regulatory Subunits 1 (PSMD1) and 3 (PSMD3) as Putative Targets for Cancer Prognosis and Therapy. Cells. 2021; 10(9):2390. https://doi.org/10.3390/cells10092390 Chicago/Turabian Style Rubio, Andres J., Alfonso E. Bencomo-Alvarez, James E. Young, Vanessa V....