As proteasome-mediated degradation regulates the turnover of numerous cellular proteins involved in essentially all cellular processes, its own regulation plays key roles in preserving homeostasis. Proteasome activity is regulated at several levels, ranging from its abundance, i.e., the synthesis of its...
The 26S proteasome is involved in degrading and regulating the majority of proteins in eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity. In this Review, we discuss the principles that underly substrate recognition and ATP-dependent degradation by the proteasome. We...
Theubiquitin/26Sproteasomepathwayisanefficientpathwayforproteindegradation,whichmainlyre-Abstract sponsiblefortheselectivedegradationofmanyproteinsineukaryoticcells.Ubiquitinmoleculesurgetargetprotein polyubiquitinatedbytheactionofubiquitin-activatingenzyme,E1,ubiquitin-conjugatingenzyme,E2,andubiqui- ...
Here, we describe a new strategy of targeted protein degradation through direct substrate recruitment to the 26S proteasome. The proteolytic complex is essential and abundantly expressed in all cells; however, proteasomal ligands remain scarce. We identify potent peptidic macrocycles that bind directly ...
(TICC), The Rappaport Faculty of Medicine and Research Institute, Haifa, Israel The 26S proteasome is a large, ~2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the de- grading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic...
responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman’s syndrome ...
Proteasome-dependent degradation serves an essential role in the removal of a wide variety of key nuclear and cytosolic proteins. Substrates are targeted for proteolysis by the ubiquitin pathway before being degraded by the 26 S proteasome. RPN6 associates with an ATPase subunit of the 19S proteaso...
DS5a | Drosophila 26S proteasome subunit Rpn10 国产/进口: 进口 产地/品牌: agrisera 型号: AS01012 参考报价: 询价 销售商: 北京启维益成科技有限公司 总点击数: 466 更新日期: 2024-12-05 产品类别: 植物试剂 性能参数 product information background Proteasome-dependent degradation serves ...
兔抗果蝇26S酶复合体亚基S5a多克隆抗体,Background Proteasome-dependent degradation serves an essential role in the removal of a wide variety of key nuclear and cytosolic proteins. Substrates are targeted for proteolysis by the ubiquitin pa
MAPK phosphorylation-induced stabilization of ACS6 protein is mediated by the non-catalytic C-terminal domain, which also contains the cis-determinant for rapid degradation by the 26S proteasome pathway. Plant J. 54, 129–140 (2008). Article CAS PubMed Google Scholar ...