The 26S proteasome is the end point of the ubiquitin- and ATP-dependent degradation pathway. The 26S proteasome complex (26S PC) integrity and function has been shown to be highly dependent on ATP and its homolog nucleotides. We report here that the redox molecule NADH binds the 26S PC ...
The carboxyl-terminal region of ODC presumably exposed by interaction with AZ plays a critical role for being trapped by the 26S proteasome. Thus, the degradation pathway of ODC proceeds as a sequence of multiple distinct processes, including recognition, sequestration, unfolding, translocation, and ...
MAPK phosphorylation-induced stabilization of ACS6 protein is mediated by the non-catalytic C-terminal domain, which also contains the cis-determinant for rapid degradation by the 26S proteasome pathway. Plant J. 54, 129–140 (2008). Article CAS PubMed Google Scholar ...
Proteasome-dependent degradation serves an essential role in the removal of a wide variety of key nuclear and cytosolic proteins. Substrates are targeted for proteolysis by the ubiquitin pathway before being degraded by the 26 S proteasome. RPN6 associates with an ATPase subunit of the 19S proteaso...
pathway, the protein unfoldase Cdc48 (or p97/VCP in higher eukaryotes) has been implicated in ATP-dependent degradation2, yet how these molecular machines of the AAA+ (ATPases associated with diverse cellular activities) family collaborate within the ubiquitin-proteasome system remains largely ...
protein degradation26S/20S proteasomesATP depletionfly agingAging is associated with loss of quality control in protein turnover. The ubiquitin-proteasome pathway is critical to this quality control process as it degrades mutated and damaged proteins. We identified a unique aging-dependent mechanism ...
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Theubiquitin/26Sproteasomepathwayisanefficientpathwayforproteindegradation,whichmainlyre-Abstract sponsiblefortheselectivedegradationofmanyproteinsineukaryoticcells.Ubiquitinmoleculesurgetargetprotein polyubiquitinatedbytheactionofubiquitin-activatingenzyme,E1,ubiquitin-conjugatingenzyme,E2,andubiqui- ...
Proteasome-dependent degradation serves an essential role in the removal of a wide variety of key nuclear and cytosolic proteins. Substrates are targeted for proteolysis by the ubiquitin pathway before being degraded by the 26 S proteasome. RPN6 associates with an ATPase subunit of the 19S proteaso...
The 26S proteasome is a large, ∼2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nuclear and membrane proteins in all eukaryotic organisms. ...