Compared with [~(212)Pb]Pb-PSMA-617, [~(212)Pb]Pb-NG001 displayed a similar binding and internalization in C4-2 cells, with comparable tumour uptake in mice bearing C4-2 tumours, but almost a 2.5-fold lower kidney uptake. Due to the rapid normal tissue clearance and tumour cell ...
The aim of this preclinical study was to evaluate the therapeutic potential of Pb-212-NG001 in multicellular tumour spheroid and mouse models of prostate cancer. The cytotoxic effect of Pb-212-NG001 was tested in human prostate C4-2 spheroids. Biodistribution at various time points and ...