18、通过结合同源建模、分子对接和结合自由能计算的整合方法,预测奈非那韦是2019-nCov主蛋白酶的潜在抑制剂 Nelfinavir was predicted to be a potential inhibitor of 2019-nCov main protease by an integrative approach combining homology modelling, m...
Xiaolong Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhengli Shi, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu, Tianlei Ying bioRxiv 2020.01.28.923011; doi: doi.org/10.1101/2020.01 4、新型冠状病毒(2019-nCoV)的全基因组进化分析否定了近期重组事件导致病毒出现的假设 Full-genome evolutio...
Zhengli Shi, Yun Zhu, Shibo Jiang & Lu Lu Cell Research volume 30, pages 343–355 (2020)Cite this article 172k Accesses 1169 Altmetric Metrics details Abstract The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious...
Schematic representation of the 2019-nCoV S protein. SP signal peptide, RBD receptor-binding domain, RBM receptor-binding motif, FP fusion peptide, HR1 heptad repeat 1, HR2 heptad repeat 2, TM transmembrane domain, CP cytoplasm domain. The residue numbers of each region correspond to their ...
核心内容:首次报告SARS-CoV特异性人类单克隆抗体CR3022可以与2019-nCoV RBD(6.3 nM的KD)有效结合。但是一些针对SARS-CoV ACE2结合位点的最有效的SARS-CoV特异性中和抗体(例如,m396,CR3014)未能结合2019-nCoV spike蛋白。说明,2019-nCoV的蛋白与SARS的相应蛋白还是不同的。
Xiaolong Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhengli Shi, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu, Tianlei Ying 4、新型冠状病毒(2019-nCoV)的全基因组进化分析否定了近期重组事件导致病毒出现的假设 Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rej...
Xiaolong Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhengli Shi, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu, Tianlei Ying bioRxiv 2020.01.28.923011; doi: https://doi.org/10.1101/2020.01.28.923011 4、新型冠状病毒(2019-nCoV)...
thus calling for the development of safe and effective therapeutics and prophylatics.1,2 Similar to severe acute respiratory syndrome(SARS)-CoV,2019-nCoV belongs to lineage B betacoronavirus,and it has the ability to utilize human angiotensin-converting enzyme 2(ACE2)as a receptor to infect hu...
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 800 laboratory-confirmed human infections, including 25 deaths, posing a serious threat to human health. Currently, however, there is no specific antiviral treatment or vaccine. Considering the relatively high identity of ...
Xiaolong Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhengli Shi, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu, Tianlei Ying bioRxiv 2020.01.28.923011; doi: https://doi.org/10.1101/2020.01.28.923011 4、新型冠状病毒(2019-nCoV)...