别名 2-苯乙炔磺酰胺 | 2-苯乙炔磺胺 英文别名 64984-31-2 | Pifithrin-mu | 2-Phenylethynesulfonamide | 2-phenylacetylenesulfonamide | Pifithrin- | I | phenylethynesulfonamide | Pifithrin-micro | Phenylethynsulfonic Acid Amide | NSC 303580 | 2-phenylethyne-1-sulfonamide | NSC303580 | PFT |...
2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. The type of cell death and the molecular cascades activated by this compound are controversial. Here, we demonstrate PES elicits a caspase- and BAX/BAK-independent non-necro...
The small molecule 2-phenylethynesulfonamide (PES) was originally identified as the inhibitor of p53 effects on the mitochondrial death pathway. In this report we demonstrate that p53 protein from PES-treated cells was detected in reduced mobility bands between molecular weights 95–220 kDa. ...
HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma. Cell Death Dis 2013;4:e730.Granato M, Lacconi V, Peddis M, Lotti LV, Renzo LD, Gonnella R, Santarelli R, Trivedi P, Frati L, D’Orazi G, Faggioni ...