Bioisoteric replacement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small heterocyclic rings has led to novel series of fused tricyclic benzoxazines which are potent 5-HT(1A/B/D) receptor antagonists with and without concomitant human serotonin transporter (hS...
生化机理高效,高度选择性的5-HT 4受体拮抗剂(pK b = 8.8)。相对于5-HT 1A,5-HT 1B,5-HT 2A,5-HT 2C和5-HT 3受体显示> 300倍的选择性。减少饮水量并增强饮用能力。 储存温度-20°C储存 运输条件超低温冰袋运输 作用类型拮抗剂 作用机制5-HT 4 受体拮抗剂 ...
生化机理PRX-08066 是一种选择性 5- 羟色胺受体 2B(5-HT2BR)拮抗剂,能选择性地扩张肺动脉血管。与 MCT 对照组动物相比,PRX-08066 在 50 毫克/公斤和 100 毫克/公斤的剂量下可明显降低 PA 峰值压力(P < 0.05 和 < 0.01)。5-HT2BR拮抗剂PRX-08066能明显减轻PA压力的升高和RV肥大,并维持心脏功能。PRX...
N-Methyl amisulpride (Amisulpride impurity H) 是一种 5-HT7 receptor、D2 receptor和 D3 receptor拮抗剂,可用于研究急性精神分裂症。 规格价格库存数量 10 mg¥ 3,228期货 50 mg¥ 9,798期货 100 mg¥ 16,683期货 大包装 & 定制 实验操作小课堂 ...
基本信息 中文名称 SB 204741,5-HT 2B受体拮抗剂 英文名称 SB 204741 中文别名 N-(1-甲基-1H-5-吲哚基)-N′-(3-甲基-5-异噻唑基)脲 CAS号 152239-46-8 分子量 286.35 分子式 C14H14N4OS 安全信息 储存条件 +2°C to +8°C 运输方式 +2°C to +8°C品牌...
5-氯-2-[(2-羟基-1-萘基)偶氮]-4-甲基苯磺酸钙盐3) 5-chloro-2-[(2-hydroxy-1-naphthalenyl)azo]-4-methyl-benzenesulfonic acid strontium salt 5-氯-2-[(2-羟基-1-萘基)偶氮]-4-甲基苯磺酸锶盐4) 2,2'-Dichloro-4-[(3-carboxy-4-hydroxyphenyl)azo]-4'-[(2-amino-8-hydroxy-6-sulfona...
5-HT6 receptor antagonists. Design, synthesis, and structure-activity relationship of substituted 2-(1-methyl-4-piperazinyl)pyridines 来自 NCBI 喜欢 0 阅读量: 2 作者:M Galezowski,CH Fabritius,U Pesonen,H Salo,M Olszak-Plachta,K Czerwinska,J Adamczyk,M Krol,P Prusis,M Sieprawska-Lupa ...
6-[(2-Chloropyridin-5-ylmethyl)(ethyl)azanyl]-4-(2-fluorophenyl)-1-methyl-5-nitro-1,2,3,4-tetrahydropyridin-2-one The article offers information on the crystal structure of the organic compound 6-[(2-Chloropyridin-5-ylmethyl)(ethyl)-azanyl]-4-(2-fluorophenyl)-1-methyl-... Chuan-Wen...
This study examined the effects of feeding conditions on sensitivity to the direct-acting 5-HT(2A/2C) receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM; 0.1-3.2 mg/kg) and the direct-acting dopamine D3/D2 receptor agonist quinpirole (0.0032-0.32 mg/kg). Male ...
1%B-SUBSTITUTED(&S)-2,3,5,6,9,1%A,1%B-OCTAHYDRO-8H-2-(1-METHYLETHYLE)-((R)-METHYLPROPHYL)-3,6-DIOXOOXAZOLO(3,2--A)PYROLO-(2,1C)PYRAZINY AND METHOD OF THEIE... JC Benes,MC Beran 被引量: 0发表: 1986年 2′,3′,4′,9′-Tetrahydrospiro[cyclohexane-1,1′-(1 h )...