Davoodpour P , Landstrom M ( 2005 ) 2-Methoxyestradiol-induced apoptosis in prostate cancer cells requires Smad7 . J Biol Chem 280 : 14773 – 14779Davoodpour P,Landstrom M.2-Methoxyestradiol induced apoptosis in prostate cancer cells requires Smad.Journal of Biological Chemistry. 2005...
[3] Kamath K,Okouneva T, Larson G, et al. 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Mol Cancer Ther. 2006 Sep;5(9):2225-33. doi: 10.1158/1535-7163.MCT-06-0113(IF:4.856). ...
2-Methoxyestradiol (2-ME2) 是一种口服生物可利用的雌二醇代谢物,具有抗肿瘤活性。它通过减少内皮细胞增殖和诱导内皮细胞凋亡来抑制血管生成,也可破坏微管的稳定。它可诱导半胱天冬酶活化,导致细胞周期停滞在 G2 期、DNA 断裂和细胞凋亡。 规格价格库存数量 ...
Mol Cancer Ther. 2006 Sep;5(9):2225-33. [2]. Aquino-Gálvez A, et al. Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncol Rep. 2016 Jan;35(1):577-83. [3]. Xu L, et al. 2-Methoxyestradiol ...
in Syrian hamster embryo (SHE) fibroblasts through concentration-dependent inhibition of cell growth. Moreover, 2-MeOE2 has demonstrated anti-proliferative activity against estrogen-responsive breast cancer cell line MCF-7 and subsequent inhibition of the growth of tumors subcutaneously inoculated in mice...
Cancer cell linesGI50 0.7 μM Concentration required to inhibit the growth of HOP-6 human lung cancer cells by 50% [PMID: 16078843] DU-145GI50 1.2 μM Antiproliferative activity against human DU145 cells at 96 hrs by WST1 assay [PMID: 22247790] ...
[6]. Chen Y, et al. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ. 2008;15(1):171-182. 品牌介绍: • MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿*全的高品质小分子活性化合物...
2-Methoxyestradiol (2-MeOE2), an endogenous metabolite of 17β-estradiol (E2), is an inhibitor of microtubule assembly that inhibits the polymerization of tubulin and interferes with mitotic spindle dynamics leading to the blockage of mitosis of human cancer cells which lack estrogen receptors in ...
2-Methoxyestradiol (2-MeOE2), an endogenous metabolite of 17β-estradiol (E2), is an inhibitor of microtubule assembly that inhibits the polymerization of tubulin and interferes with mitotic spindle dynamics leading to the blockage of mitosis of human cancer cells which lack estrogen receptors in ...
Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ. 2008;15(1):171-182. 品牌介绍:• MCE (MedChemExpress) 拥有200 多种全球独家化合物,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;• 50,000 多种高选择性...