L-2-Hydroxyglutarate dehydrogenase : identification of a novel enzyme activity in rat and human liver. Implications for L-2-hydroxyglutaric acidemia - Jansen, Wanders - 1993Jansen GA, Wanders RJA (1993) L -2-Hydroxyglutarate dehydrogenase: identification of a ...
during the course ofmacrophage activation. The buildup of D-2HG may be further explained by reduced expression of D-2HGDehydrogenase(D2HGDH), which converts D-2HG back into αKG, and showed inverse kinetics with HOT and D-2HG levels.We tested the immunomodulatory effects of D-2HG during...
l-Serine biosynthesis, a crucial metabolic process in most domains of life, is initiated by d-3-phosphoglycerate (d-3-PG) dehydrogenation, a thermodynamically unfavorable reaction catalyzed by d-3-PG dehydrogenase (SerA). d-2-Hydroxyglutarate (d-2-HG) is traditionally viewed as an abnormal meta...
-2-hydroxyglutarate dehydrogenase from P. aeruginosa (PaD2HGDH). Knockout of PaD2HGDH impedes P. aeruginosa growth, making PaD2HGDH a potential target for therapeutics. Previous studies showed that the enzyme's activity increased with Zn2+
Background: The role of R-2-hydroxyglutarate (R-2HG), which is derived from mutant isocitrate dehydrogenase 1/2 (IDH1/2) enzymes, is controversial in myeloid madoi:10.2139/ssrn.3696871Zhu, ShuanghongMei, ChenJiang, LingxuYang, Wenli
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain cancers. These mutations occur at a single amino acid residue of the IDH1 active site, resulting in loss of the enzyme’s ab
2HG occurs as two enantiomers, and somatic mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 result in stereospecific production of the D-enantiomer (D2HG) in glioma and acute myeloid leukemia (AML) (Dang et al., 2009; Figueroa et al., 2010). In contrast, the L-enantiomer (...
M. Isocitrate dehydrogenase mutation and (R)-2-hydroxyglutarate: from basic discovery to therapeutics development. Annu. Rev. Biochem. 86, 305–331 (2017). Article CAS PubMed Google Scholar Ward, P. S. et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a ...
中文名称:2-hydroxyglutarate dehydrogenase 中文同义词: 英文名称:2-hydroxyglutarate dehydrogenase 英文同义词:2-hydroxyglutarate dehydrogenase CAS号: 分子式: 分子量:0 EINECS号: Mol文件:Mol File 2-hydroxyglutarate dehydrogenase 信息错误报告 提交 按省份浏览2-hydroxyglutarate dehydrogenase供应商 ...
The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation. Here, we identify an additional activity of R-2-HG: tumor cell–derived R-2-HG is taken up by T cells where it induces a perturbati...