Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humanselectrophilesreactive aldehydeoxidative damagehumans2-hydroxybenzylamine.Inflammation is associated with the formation of reactive oxygen species (ROS) and the formation of lipid-derived compounds, such as isolevu...
John A. Rathmacher a fFood and Chemical ToxicologyFuller JC, Pitchford LM, Morrison RD, Daniels JS, Flynn CR, Abumrad NN, et al. In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate. Food Chem Toxicol. 2018;121:541-548....
Abumrad, Naji N.Rathmacher, John A.Elsevier ScienceRegulatory Toxicology and PharmacologyFuller JC, Pitchford LM, Abumrad NN, Rathmacher JA. Subchronic (90-day) repeated dose toxicity study of 2-hydroxybenzylamine acetate in rats. Regulatory Toxicology and Pharmacology. 2018;99:225-232....
Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trialSafetyPharmacokineticsHumansSalicylamineγ-KetoaldehydesDemographic Characteristicsdoi:10.1186/s40360-020-0382-yLisa M. Pitchford...
In a series of rodent toxicity studies, 2-HOBA acetate was well-tolerated and did not produce any toxic effects over 28 or 90 days of repeated oral administration. However, it remained necessary to test the potential toxicity of 2-HOBA acetate in a non-rodent species. In this investigation,...