John A. Rathmacher a fFood and Chemical ToxicologyFuller JC, Pitchford LM, Morrison RD, Daniels JS, Flynn CR, Abumrad NN, et al. In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate. Food Chem Toxicol. 2018;121:541-548....
Animals were treated with 1.45 or 4.35 mg/ml 2-HOBA-acetate, which corresponds to 1.0 and 3.0 mg/ml 2-HOBA, respectively, in the drinking water, beginning 7 days after the first infection. 2-HOBA supplementation was maintained until the end of the experiments and the solutions were changed...
Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humanselectrophilesreactive aldehydeoxidative damagehumans2-hydroxybenzylamine.Inflammation is associated with the formation of reactive oxygen species (ROS) and the formation of lipid-derived compounds, such as isolevu...
First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteersSafety, Pharmacokinetics, Humans, Salicylamine, γ-KetoaldehydesBackground2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of ...
In a series of rodent toxicity studies, 2-HOBA acetate was well-tolerated and did not produce any toxic effects over 28 or 90 days of repeated oral administration. However, it remained necessary to test the potential toxicity of 2-HOBA acetate in a non-rodent species. In this investigation,...
Rathmacher John A.Fuller John C.Regulatory Toxicology and PharmacologyPitchford LM, Smith JD, Abumrad NN, Rathmacher JA, Fuller JC Jr. Acute and 28-day repeated dose toxicity evaluations of 2-hydroxybenzylamine acetate in mice and rats. Regul Toxicol Pharmacol. 2018....