2-Hydroxyacyl-CoA lyase (HACL1) is a key enzyme of the peroxisomal 伪-oxidation of phytanic acid. To better understand its role in health and disease, a mouse model lacking HACL1 was investigated. Under normal conditions, these mice did not display a particular phenotype. However, upon ...
2-Hydroxyphytanoyl-CoA lyase (abbreviated as 2-HPCL), renamed to 2-hydroxyacyl-CoA lyase (abbreviated as HACL1), is the first peroxisomal enzyme in mammals that has been found to be dependent on TPP (thiamin pyrophosphate). It was discovered in 1999, when studying alpha-oxidation of phytanic...
Fraccascia, P.; Casteels, M.; de Schryver, E.; van Veldhoven, P.P. Role of thiamine pyrophosphate in oligomerisation, functioning and import of peroxisomal 2-hydroxyacyl-CoA lyase. Biochim. Biophys. Acta 2011, 1814, 1226-1233. [CrossRef] [PubMed]...
2-Hydroxyacyl-CoA lyase (HACL1) is a key enzyme ofBaesKatholiekeMyriamKatholiekeVanKatholiekeVeldhovenKatholiekePaulKatholiekeP.KatholiekeMorvayKatholiekePetrutaKatholiekeL.KatholiekeMeyhiKatholiekeBiochimica et Biophysica Acta. Molecular and cell biology of Lipids...