To address intrinsic limitations of native C1 biocatalysts, here we report that 2-hydroxyacyl CoA lyase (HACL), an enzyme involved in mammalian 伪-oxidation, catalyzes the ligation of carbonyl-containing molecules of different chain lengths with formyl-coenzyme A (CoA) to produce C1-elongated 2-...
2-Hydroxyacyl-CoA lyase (HACL1) is a key enzyme ofBaesKatholiekeMyriamKatholiekeVanKatholiekeVeldhovenKatholiekePaulKatholiekeP.KatholiekeMorvayKatholiekePetrutaKatholiekeL.KatholiekeMeyhiKatholiekeBiochimica et Biophysica Acta. Molecular and cell biology of Lipids...
Fraccascia, P.; Casteels, M.; de Schryver, E.; van Veldhoven, P.P. Role of thiamine pyrophosphate in oligomerisation, functioning and import of peroxisomal 2-hydroxyacyl-CoA lyase. Biochim. Biophys. Acta 2011, 1814, 1226-1233. [CrossRef] [PubMed]...
2-Hydroxyacyl-CoA lyase (HACL1) is a key enzyme of the peroxisomal 伪-oxidation of phytanic acid. To better understand its role in health and disease, a mouse model lacking HACL1 was investigated. Under normal conditions, these mice did not display a particular phenotype. However, upon ...