It first uses methyl, benzyl or tert-butyl to protect the phenolic hydroxyl, the parivis which is protected by the phenolic hydroxyl reacts with the magnesium in the ether, tetrahydrofuran, tert-butyl methyl ether, isopropyl ether and its mixing solution to obtain the Grignard reagent, the ...
2-ethanediyl), alpha-sulfo- omega -hydroxy-poly(oxy- ether with phenol 1-(me thylphenyl)ethyl derivs., ammonium salts poly(oxy-1,2-ethanediyl), alpha-sulfo- omega -hydroxy-,ether with phenol 1-(methylphenyl)ethyl derivs., ammonium salts ...
Me = methyl NMP = N-methylpyrrolidone Et = ethyl DCM = dichloromethane Pr = n-propyl n-BuLi = n-butyllithium Bu = n-butyl Pd/C = palladium on carbon TMS = trimethylsilyl TEA = triethylamine Et2O = diethyl ether min = minute(s) HOAc or AcOH = acetic h or hr = hour(s) acid L ...
ethyl methyl ether of formula II with a de-tert-butylation agent such as hydrochloric acid, hydrogen chloride or sulfuric acid or by adding a de-tert-butylation catalyst such as p-toluenesulfonic acid, methanesulfonic acid or strongly acidic ion exchange resin to the above ether and distilling ...
4-Methoxy-2-ethyl phenol of formula (I) is prepared from a 2-methoxy ethyl halide of formula CH3OCH2CH2X (II) (where X is Cl, Br or I). (II) is treated with Mg to form the corresp, halide. This is treated with a bromophenol ether of formula (III) (where R is a group that...
% hydrophilic or hydrophobic polymer(s) (II) as matrix former; and have a specific in vitro (I) release profile over 24 hours and/or contain a cellulose ether and/or cellulose ester. Delayed release pharmaceutical formulations (A) comprise 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol...
This is treated with a bromophenol ether of formula (III) (where R is a group that is easily removed below 70 deg.C by acid) to give 4-(2-methoxy ethyl)phenol ether offormula (IV) which is treated with an acid to give (I). The reaction in which R is a tetrahydropyranyl, ...
in the presence of 1.1-2.0 mole alkali-metal-methylate or alkali-metal-hydroxide, reducing the 4-nitro-(methyl-beta-phenyl-ether) so obtd., diazotating the resulting 4-amino-(methyl-beta-phenyl -ethyl-ether) and boiling down the reaction mixt.TOKAR,GEZA,HU...
in the presence of 1.1-2.0 mole alkali-metal-methylate or alkali-metal-hydroxide, reducing the 4-nitro-(methyl-beta-phenyl-ether) so obtd., diazotating the resulting 4-amino-(methyl-beta-phenyl -ethyl-ether) and boiling down the reaction mixt.TOKAR,GEZA,HU...