2-BP is one of the most commonly used palmitoylation inhibitors, which can directly and irreversibly inhibit the palmitoyltransferase activity of all DHHC (Asp-His-His-Cys) proteins27. In this study, we not only found that chemotherapy-induced pyroptosis was mediated by the BAK/BAX-caspase-3-...
Alonso AM, Coceres VM, De Napoli MG, Nieto Guil AF, Angel SO, Corvi MM. Protein palmitoylation inhibition by 2-bromopalmitate alters gliding, host cell invasion and parasite morphology in Toxoplasma gondii. Mol Biochem Parasitol. 2012Alonso AM, Coceres VM, De Napoli MG, Nieto Guil AF, Angel...
Subsequently, we investigated the effect of 2-bromopalmitate (2BP), a small-molecular inhibitor of protein palmitoylation, on the behavior of Fadu cells in vitro (50 渭M) and in nude mouse xenograft models (50 渭mol/kg), and found that 2BP suppressed the proliferatio...
Protein palmitoylation is one of the mechanisms by which the DNA damage response is regulated. Therefore, we hypothesized that protein palmitoylation played a role in regulation of the senescent phenotype. Here, we showed that treatment of senescent human vascular smooth muscle cells (VSMCs) with ...
The present invention provides a method of inhibiting Fyn/Lck fatty acylation and protein palmitoylation in a cell in an individual in need of such treatment comprising the step of administering to said individual a pharmacologically effective dose of 2-bromopalmitate. Also provided is a method of ...
The present invention provides a method of inhibiting Fyn/Lck fatty acylation and protein palmitoylation in a cell in an individual in need of such treatment comprising the step of administering to said individual a pharmacologically effective dose of 2-bromopalmitate. Also provided is a method of ...
Interestingly, GSDME was found to be palmitoylated on its C-terminal (GSDME-C) during chemotherapy-induced pyroptosis, while 2-bromopalmitate (2-BP) could inhibit the GSDME-C palmitoylation and chemotherapy-induced pyroptosis. Mutation of palmitoylation sites on GSDME also diminished the pyroptosis ...
The present invention provides a method of inhibiting Fyn/Lck fatty acylation and protein palmitoylation in a cell in an individual in need of such treatment comprising the step of administering to said individual a pharmacologically effective dose of 2-bromopalmitate. Also provided is a method of ...
The present invention provides a method of inhibiting Fyn/Lck fatty acylation and protein palmitoylation in a cell in an individual in need of such treatment comprising the step of administering to said individual a pharmacologically effective dose of 2-bromopalmitate. Also provided is a method of ...
The present invention provides a method of inhibiting Fyn/Lck fatty acylation and protein palmitoylation in a cell in an individual in need of such treatment comprising the step of administering to said individual a pharmacologically effective dose of 2-bromopalmitate. Also provided is a method of ...