2-aminopurine (2AP) is a fluorescent nucleobase that provides the means to probe structure and dynamics of RNA molecules. Because 2AP can base pair with Uridine, it can replace normal A:U pairs without substantial deformation of duplexes. It is best used as a probe of ostensibly single-...
2-Aminopurine,2-氨基嘌呤(2-AP)可用于双链RNA依赖性蛋白激酶、蛋白激酶R(PKR)的特异性抑制。 AbMole成立于美国休斯敦,经过10年发展,拥有超过8000个高品质现货抑制剂、激动剂(大包装产品价格极优惠);其高品质的人源化单抗
Summary The fluorescence of the base analog 2-aminopurine (2AP) is used in highly sensitive assays to determine kinetic parameters for DNA polymerase catalyzed reactions, including exonucleolytic proofreading and nucleotide binding and incorporation. Since 2AP fluorescence can also be used to probe DN...
Results of quantum-chemical studies, aimed at the elucidation of the key microstructural mechanisms of the mutagenicity of 2AP, have been summarized here. In this context, for the first time it was outlined the most important surveys: Why 2AP is incorporated into DNA in trace concentrations?
The kinetics of promoter binding and open complex formation in bacteriophage T7 RNA polymerase was investigated using 2-aminopurine (2-AP) modified promoters. 2-AP serves as an ideal probe to measure the kinetics of open complex formation because its fluorescence is sensitive to both base-unpairing...
exquisite sensitivity of the quantum yield of the fluorescent nucleotide base analog, 2-aminopurine (2-AP), to its immediate structural and dynamic ... HW Lee,KT Briggs,JP Marino - 《Methods》 被引量: 13发表: 2009年 Probing dynamics of HIV-1 nucleocapsid protein/target hexanucleotide complexes...
We have investigated the UV vibronic spectra and excited-state nonradiative processes of the 7H- and 9H-tautomers of jet-cooled 2-aminopurine (2AP) and of the 9H-2AP-d 4 and -d 5 isotopomers, using two-color resonant two-photon ionization spectroscopy at 0.3 and 0.045cm1 resolution. Th...
Examines the excited-state properties of 2-aminopurine (2AP) in a B-form dinucleotide. Impact of base stacking on 2AP fluorescence quenching; Effect of dif... Jean,M John,Hall,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 186发表: 20...
The population of 2-aminopurine · hydroxymethylcytosine (AP · C††Abbreviations used: AP, A, T, C and G refer to 2-aminopurine, adenine, thymine, hydroxymethylcytosine and guanine nucleotides, respectively, in discussion of base-pairing; HMdCTP, hydroxymethyldeoxycytidinetriphosphate; dATP, ...
Chemical Name: 2,6-Diaminopurine 2'-deoxyriboside Synonyms 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-9H-purin-2,6-diamine;Cladribine EP Impurity A;Nsc104303;2-NH2-2'-dA;Kraqubin impurity 1;2-NH2-2'-deoxyadenosine;2-NH2-2"-deaxyadenosine;2,6-Diaminopurine 2'-deo;2'-Deoxy-2-amino...