2-(Benzylthio)-N-(2-morpholinoethyl)ethan-1-amine2-(苄硫基)-N-(2-吗啉代乙基)乙-1-胺1799787-08-8 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]amino]-3-cyclobutene-1,2-dione3-[[3,5-双(三氟甲基)苯基]氨基]-4-[[((1R,2R)-2-(1-吡咯...
2-Bromo-1-(pentafluorophenyl)ethan-1-one (2.89 g, 10.0 mmol) and 2-amino-1,3,4-thiadiazole-5-sulfonamide (1.80 g, 10.0 mmol) were refluxed in ethanol (20 mL) for 60 hrs. Solvent was evaporated and the crude solid was purified by flash chromatography using 20:80:0.1 ethyl acetate: ...
1-adamantylmethyl methanesulfonate N1-(3,4-dimethoxyphenethyl)-3-methyl-4-nitrobenzamide methyl 5-(4-chlorophenyl)-3-[(2,2,2-trifluoroacetyl)amino]thiophene-2-carboxylate N3-[3,5-di(trifluoromethyl)phenyl]-5-nitrothiophene-3-carboxamide
The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non
2,2'-(Oxatriethylenedioxa)-di-(phenylethyl)-N-adamantylamido phosphate calcium complex 2,2'-(Oxybis(2,1-Ethanediyloxy)) Bisethanol 2,2'-(Oxybis(2,1-ethanediyloxymethylene)) bisoxirane 2,2'-(Oxybis(ethyleneoxymethylene)) bisoxirane 2,2'-(Oxybis(methylene)) bisoxirane 2,2'-(p...
To accumulate the SAR information around the C-7 position, we substituted the methyl group in 15, respectively, with a larger group such as a cyclopropyl, cyclohexyl, adamantyl and pyridin-3-yl group, and compounds 23–26 were prepared. Modification of the R moiety on 7(S)-7-sulfur-Ph-...
To accumulate the SAR information around the C-7 position, we substituted the methyl group in 15, respectively, with a larger group such as a cyclopropyl, cyclohexyl, adamantyl and pyridin-3-yl group, and compounds 23–26 were prepared. Modification of the R moiety on 7(S)-7-sulfur-Ph-...
1-(1-adamantyl)ethanamine 1-金刚烷乙胺 13392-28-4 METHYL 6-CHLORO-4-METHOXYPICOLINATE 6-氯-4-甲氧基-2-吡啶羧酸甲酯 204378-41-6 8-bromo-2-chloroquinoxaline 8-溴-2-氯喹恶啉 1092500-67-8 3,6-dichloropyridazine-4-carboxamide 3,6-DICHLOROPYRIDAZINE-4-CARBOXAMIDE 27427-66-3 3,5-di...
Exemplary cycloalkyl groups include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, norbornyl, adamantyl, cyclohexyl, cyclooctyl, etc. “Derivative” refers to a compound that is derived from some parent compound where one atom is replaced with another atom or group of atoms and ...
2-Bromo-1-(pentafluorophenyl)ethan-1-one (2.89 g, 10.0 mmol) and 2-amino-1,3,4-thiadiazole-5-sulfonamide (1.80 g, 10.0 mmol) were refluxed in ethanol (20 mL) for 60 hrs. Solvent was evaporated and the crude solid was purified by flash chromatography using 20:80:0.1 ethyl acetate:...