7 A, B). This observation suggests that ciliated cells could differentiate after the first wave of infection and provide new target cells at later time points, consistent with the findings of Hao et al.26. Interestingly, the relative TEER values fluctuated inversely to the infectious titers (...
The culture supernatant (10 µl) was harvested at the indicated timepoints and used for RT–qPCR to quantify the viral RNA copy number (see “RT–qPCR” section below). In the infection experiments using human iPSC-derived airway and lung epithelial cells (Fig. 5g, h), working viruses...
Emerging evidence points toward an intricate relationship between the pandemic of coronavirus disease 2019 (COVID-19) and diabetes. While preexisting diabetes is associated with severe COVID-19, it is unclear whether COVID-19 severity is a cause or consequence of diabetes. To mechanistically link ...
According to the preceding points, this representation of the “sense” object can do nothing but form a circle with the latter but is determined-in-the-last-instance by the sense of this “sense” object. As for these latter, the “sense” object and its sense–the sense of sense–are...
The peptides were purchased from “Sigma-Aldrich” in Japan and their isoelectric points (pI) were estimated by “GENETYX” (Ver. 10). To obtain microdomain fraction of unfertilized eggs, the eggs were subjected to the preparation of membrane microdomains as described previously (Sato et al.,...
abject points towards a domain which is the source of our life-intensity – we draw our energy out of it, but we have to keep it at the right distance. If we exclude it, we lose our vitality, but if we get too close to it, we are swallowed by the self-destructive vortex of madn...
Miller, MD, MBA, MPH JAMA Health Forum In the News Experts Offer Advice to Shore Up Confidence in COVID-19 Vaccines Joan Stephenson, PhD JAMA Health Forum Key Points Question Is the Ad26.COV2.S vaccine immunogenic in humans, how quickly does it raise antibody responses, and what types ...
Inspired by Mecca’s Grand Mosque (Masjid al-Haram), this gigantic 1960’s elegant mosque accommodates up to 15,000 worshippers. Famed for its umbrella-like blue-tile roof with 18 points symbolising the 13 states of Malaysia and the five pillars of Islam, the 5x-daily call to prayer ring...
To test whether CBZ has an effect on the dyskinesia symptoms of Prrt2-mutant mice, CBZ was injected intraperitoneally at the specified time points at different doses of either 1, 5, 15, 30 mg/kg body weight, of which 15 mg/kg was found to have appropriate action with significant inhibit...
AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic AMPK exists as αβγ complexes, whose regulatory γ subunit confers energy sensor function by binding adenine nucleotides. Humans bearing activa