N-(2-MORPHOLIN-4-YLETHYL)(PHENYLCYCLOPENTYL)FORMAMIDE 696631-88-6 C18H26N2O2 3-CHLORO-5-(TRIFLUOROMETHYL)-2-(4-(4-(TRIFLUOROMETHYL)(3,2,5-OXADIAZOLYL))PHENOXY)PYRIDINE C15H6ClF6N3O2 N-(3-BROMOPHENYL)(PHENYLCYCLOPENTYL)FORMAMIDE C18H18BrNO 2-(4-OXO(3-HYDROQUINAZOLIN-2-YLTHIO))-N-(...
6-Dichlorobenzonitrile 2,3-Dicyano-1,4- dithiaanthraquinone Isoprothiolane 167 17109-49-8 乙基二苯二硫代磷酸脂 Ethyldiphenyl dithiophosphate 168 640-15-3 二甲硫吸磷 Thiometon 169 35400-43-2 o-乙基-o-4-甲基苯硫基-S-丙基二 o-Ethyl-o-4-methylthiophenyl-S- 硫代磷酸脂 propyl ...
The present invention is directed to novel inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds an
(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(thiophen-3-yl)pyrido-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(3,4-difluorophenyl)pyrido-[3,2-d]pyrimidine, 2-amino-4-[N-(4-chlorophenoxyacetyl)piperazin-1-yl]-6-(4-chlorophenyl)pyrido-[3,2-d]pyrimidine...
2. A compound as defined in claim 1, which is other than 7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonan-6-one. 3. A compound as defined in claim 1, wherein Ring A represents a phenyl, thiophenyl, pyrazolyl, pyridyl, indolyl, indazolyl, quinolinyl...
The present invention relates to 6-amino-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulat
6 carbon atoms wherein one or several (e.g., up to 3) carbon atoms can be substituted by hetero atoms, such as oxygen, sulfur or nitrogen. Examples for suitable aromatic and heteroaromatic residues are: phenyl, pyridinyl, thiophenyl, furanyl, pyrimidinyl, imidazolyl, pyrazolyl, and others....
The term “n-m membered” wherein n and m are integers (e.g., 6-10 membered) describes a range where the number of ring forming atoms is from n to m. For example, piperidinyl is an example of a 6-membered heterocyclyl ring, pyrazolyl is an example of a 5-membered heteroaryl ring...
6 or 7 membered saturated heterocyclyl, wherein the heterocyclyl has two ring heteroatoms independently being oxygen or sulfur and which are not directly bonded to each other, and wherein the heterocyclyl is optionally substituted by 1, 2 or 3 ring-carbon substituents independently being C1-C2al...
WO/2006/115452 November, 2006 USE OF PYRAZOLYL-PYRIMIDINE DERIVATIVES IN THE TREATMENT OF PAIN WO/2006/123113 November, 2006 PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS WO/2007/049041 May, 2007 4- (3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES FOR USE AS TYROSINE KINASE INHIBIT...