S. Therefore, the structure was determined to be 3S-5, 8-dihydroxy-3-hydroxymethyldihydroisocoumarin and was named as botryoisocoumarin A. In addition, five known compounds (2–6) were isolated and identified as monocerin (2),27 3-methyl-6,8-dihydroxyisocoumarin (3),28 8-methoxymellein ...
The thiazolidine-2,4-dione compound contemplated by the present invention is a novel compound represented by the general formula I, wherein R1 is a hydrogen atom or a methyl group. Representative examples of this compound are 5-{4-[3-(3,4-dihydroxyphenyl)-2-propenoyl]benzyl}thiazolidine-2,...
Examples of the compound having a hydroxyl group are hydroquinone, resorcinol, phloroglucin, 2,4-dihydroxybenzophenone, 2,3,4-trihydroxybenzophenone, 2,3,4,4'-tetrahydroxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, bis(p-hydroxyphenyl)methane, bis(2,4-dihydroxyphenyl)methane, bis(2,3,4...
Imines 24 were generated in situ by homocondensation of benzylamines 23 using 4,6-dihydroxysalicyclic acid as an organocatalyst and molecular oxygen as a co-oxidant. Imines 24 were then treated with acyl chlorides and triethylamine in the presence of molecular sieves in acetonitrile at 0°-rt...
The highest enantioselectivity was attained with the aromatic benzaldehyde (entry 4, ee = 96%), but the yield is significantly lower than for aliphatic aldehydes. This is mainly a consequence of the marked sensitivity towards elimination of 4-aryl substituted 2-oxetanones explaining a partial ...
Compounds such as 2- and 4-[(5-Methyl-2,4-diphenyl-2H-pyrazol-3-ylimino)-methyl]-phenol (structures (a) and (b) in Figure 1), have been evaluated as ligands in more than 700 biological assays each [14,15]. These compounds were revealed to have antileishmaniasis and antibacterial ...
molecules Article Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone- Containing Natural Product Hongchuan Zhao 1,†, Pu Sun 2,3,†, Wei Guo 2,3, Yi Wang 2, Ao Zhang 1,3,4, Linghua Meng 2,3,* and Chunyong Ding 1,3,* 1 CAS Key ...