2 2′-O-methyltransferase (2′-O-MTase; EC 2.1.1.296), which is referred to henceforth as nsp16 [10]. Non-Structural Protein 16 (nsp16), a viral RNA 2′-O-MTase, is one of the highly viable targets for the design of agents against SARS-CoV-2. Nsp16, with its cofactor nsp10,...