该研究基于氢谱核磁共振(1H-NMR)研究了妊娠期甲状腺功能减低(gestational hypothyroidism, GHT)患者脐带血代谢特征,发现了GHT相关脐带血代谢物及代谢通路变化,并以此为基础建立了GHT与相关疾病风险关系的“代谢物桥梁”,为深入认识GHT的病理及其导致相关疾病风险的路径提供了数据支持和参考。 GHT与很多疾病风险相关,但对GH...
Nuclear magnetic resonance (NMR) spectroscopy acts as the best tool that can be used in tissue engineering scaffolds to investigate unknown metabolites. Moreover, metabolomics is a systems approach for examining in vivo and in vitro metabolic profiles, which promises to provide data on cancer ...
Orphanet J Rare Dis (2021) 16:441 https://doi.org/10.1186/s13023-021-02075-x RESEARCH Open Access 1H‑NMR‑based metabolic profiling identifies non‑invasive diagnostic and predictive urinary fingerprints in 5q spinal muscular atrophy Afshin Saffari1, Claire Cannet2, Astrid ...
system. Upon endo therapy, we observed specific variations in the leaf content of some metabolites. In particular, the1H NMR-based metabolomics approach showed, after the injection, a significant decrease of both the disease biomarker quinic acid and mannitol with simultaneous increase of polyphenols ...
The 1HNMR-based metabolomic approach was capable of distinguishing between plasma samples of AP rats and SO controls, providing a new and non-invasive methodology for the study of AP.Abbreviations AP: Acute pancreatitis CPMG: Carr-Purcell-Meiboom-Gill DA: Discriminant analysis FID: Free ...
This tentative class separation could not be repeated and validated in any of the other media sets 2 to 5. CONCLUSIONS: Despite the rigorous technical approach, (1)H NMR based profiling of spent culture media cannot predict success of implantation for day 3 human embryos. 展开 ...
分析结果显示有四组代谢物可作为AKI的诊断指标。1H NMR 谱显示,与非AKI患者相比,AKI患者尿液中柠檬酸盐水平显著降低,而亮氨酸和缬氨酸水平升高。研究人员发现,病因不同的AKI不同亚型之间的代谢物谱也不相同。 一些在动物研究中被确定为AKI潜在生物标志物的代谢物(马尿酸盐、吲哚硫酸盐、肌酐)在健康对...
通过基于1H-NMR的分析研究摄入生物活性化学物质后血浆代谢组的变化 欧洲研究人员公布了最近一项NMR研究的结果,他们研究了一种生物活性物质——二十二碳六烯酸(DHA)——对被视为具有高代谢综合征风险的个体的血浆代谢组的影响。之前的研究表明,增加omega-3脂肪酸DHA的摄入量与降低代谢综合...
Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases. Sci Rep. 2017;7(1):9108.Wojtowicz W, Zabek A, Deja S, Dawiskiba T, Pawelka D, Glod M, et al. Serum and urine 1H NMR- based ... W Wojtowicz,A Zabek,S Deja,... - 《Scientific Reports》 ...
Hepatitis B virus X protein (HBx) plays an important role in HBV-related hepatocarcinogenesis; however, mechanisms underlying HBx-mediated carcinogenesis remain unclear. In this study, an NMR-based metabolomics approach was applied to systematically inve