The aim of this study was to evaluate the administration safety and radiation dosimetry of 18F-PSMA-11. Methods: Six patients (aged 62–68 y; mean, 66 ± 2 y) with suspected prostate cancer recurrence after previous treatment were administered 2 MBq of 18F-PSMA-11 per kilogram of body ...
内容提示: ·临床研究·68Ga⁃PSMA⁃11PET/CT与18F⁃FDGPET/CT诊断前列腺癌生化复发的对比研究王一宁 陈若华 陈虞梅 刘建军上海交通大学医学院附属仁济医院核医学科 200127通信作者:刘建军, Email:nuclearj@163.com【摘要】 目的 比较 68Ga⁃前列腺特异膜抗原(PSMA)⁃11PET/CT与18F⁃脱氧葡萄糖(FDG)PET/...
All mice received two PET/CT scans with both [18F]AlF-PSMA-11 and [18F]PSMA-1007 within a timeframe of 4 days (range 1–4 days). All mice were intravenously administered 9.09 ± 0.55 MBq [18F]AlF-PSMA-11 with a MA of 61.64 ± 15.83 MBq/nmol and 9.72 ± 0.67 ...
性前列腺癌的监测。目前，以PSMA 为靶点的显像剂主要是放射性核素68Ga 和18F 的化合物。该文综述了临床常用的小分子抑制剂68Ga -PSMA -11和18F -PSMA -1007的特点，以及其在前列腺癌显像中的优缺点，为临床诊断提供依据，并指导其在不同患者中的临床应用。【关键词】 前列腺癌；前列腺特异性膜抗原；正电子...
PSMA，即前列腺特异性膜抗原，是前列腺癌细胞的标志性蛋白。这种分子探针能够精确识别并结合到PSMA上，从而实现对前列腺癌细胞的精准定位。与此同时，177Lu作为一种放射性核素，能释放出具有治疗作用的β粒子，对癌细胞产生杀伤作用。在治疗过程中，177Lu-PSMA-617核素分子探针通过静脉注射进入患者体内。随着血液循环，...
左图:18F-PSMA 1007 显像;右图:18F-FDG显像。 开展此项新技术以来,已完成了近60例患者,大部分患者通过此项检查重新确定了临床分期,对治疗方案也有相应的调整。其中一名患者临床怀疑前列腺癌,通过18F-FDG PET/CT检查发现前列腺增大,18F-...
Therefore, to evaluate the therapeutic effect, a diagnostic PSMA-targeting PET imaging agent is required to monitor tumor growth inhibition. [18F]DCFPyL and [68Ga]PSMA-11 are considered PSMA target prostate cancer imaging PET tracers for therapy monitoring with [177Lu]ludotadipep. [18F]DCFPyL, ...
18F-FDG PET/CT holds better clinical potential for evaluating UTUC and detecting lymph node metastasis compared to68Ga-PSMA-11 PET/CT, likely due to the relatively scant expression of FOLH1 in tumor neovascular endothelium while the abundant expression of GLUT1 in malignancy. Furthermore, the low...
The mean SUVmax for both PSMA and FDG was 7.2±3.3 and 20.3±7.9, respectively (p<0.001). 68Ga-PSMA-11 PET/CT showed good sensitivity of 97% in detecting the primary lung lesions and a significant advantage over 18F-FDG PET for detecting brain metastases (6/11, 55% versus 0/11, 0...
Anaesthetics that compliment radiotracers [68Ga]Ga-DOTA-TATE, [18F]FDG and [68Ga]Ga-PSMA-11 PET/CT Imaging in Rodents 来自 EBSCO 喜欢 0 阅读量: 4 作者:J Visser,C Swanepoel,CHS Driver,T Ebenhan 年份: 2024 收藏 引用 批量引用 报错 分享 ...