Scheme 1. Radiosynthesis of [18F]PARPi with four different approaches [11,12,15]. Scheme 2. Reported synthesis of [18F]PARPi. [a]: [18F]fluoride, ethyl 4-nitrobenzoate (2 mg in 200 µL DMSO), 150 °C, 15 min; [b]: NaOH 1 M 0.5 mL, 1 min, RT, followed by HCl 1 M ...
PARPPET imagingRadiotracersPARP inhibitorsOncologyThese findings imply that [ 18 F]FPyPARP is an alternative to [ 18 F]PARPi and [ 18 F]FTT for PET imaging of PARP enzymes.doi:10.1007/s00259-021-05436-7Stotz, SophieKinzler, Johannes
Safety and feasibility of PARP1/2 imaging with 18F-PARPi in patients with head and neck cancerdoi:10.1158/1078-0432.CCR-19-3484Heiko M. SchderPaula Demétrio De Souza FranaReiko NakajimaEva M BurnaziSheryl RobertsChristian BrandMilan Grkovski...
Fully Automated, High-Dose Radiosynthesis of [18F]PARPi.Pacelli, AnnaZarrad, FadiWarnier, CorentinGendron, ThibaultOtabashi, MuhammadVriamont, CharlesJackson, AlexFendler, Wolfgang P.Herrmann, KenNader, MichaelPharmaceuticals (14248247)
[18F]PARPi was synthesized by nucleophilic aromatic substitution of the corresponding boc﹑rotected nitro﹑recursor followed by acidic deprotection.doi:10.1002/jlcr.3847Thomas C. WilsonNagavarakishore PillarsettyThomas ReinerJohn Wiley & Sons, LtdJournal of Labelled Compounds and Radiopharmaceuticals...
[18F]PARPi-PET in locally advanced oral cavity carcinomadoi:10.1016/j.oraloncology.2019.09.016Francesca De FeliceVincenzo TomboliniElsevier BVOral Oncology
18f f po1y adp ribose po1ymerase inhibitor radiotracers for imaging parp expression and their po10tia1 c1inica1 app1ications in onco1ogyIncluding poly(ADP-ribose) polymerase (PARP) inhibitors in managing patients with inoperable tumors has significantly improved outcomes. The PARP inhibitors hamper...