5-羟色胺受体,18F标记,18F-MPPF,合成报道了5-羟色胺(5-HT1A)受体显像剂4-[18F]氟-N-[2-[1-(2-甲氧基苯基)-1-哌嗪基乙基]-N-2吡啶基-苯甲酰胺(18F-fluoro-N-[2-[1-(2-methoxyphenyl)]-1-piperazinyl]ethyl-N-2-pridinyl-benzamide,18F-MPPF)的合成和标记.标记前体MPPNO2和各步合成中间体均...
5-HT1A 受体显像剂18F-MPPF 的制备及其生物学特性分析
[18F]MPPF and [18F]FDG μPET imaging in rats: impact of transport and restraint stress Verena Buchecker, Ann-Marie Waldron, R. Maarten van Dijk, Ines Koska, Matthias Brendel, Barbara von Ungern-Sternberg, Simon Lindner, Franz Josef Gildehaus, Sibylle Ziegler, Peter Bartenstein ...
2001. New automation of 18F-MPPF using a Coincidence syn- thesizer. J Labelled Comp Radiopharm 44:S1045.Le Bars D. , Bonmarchand G. , Alvarez J. M. , Lemaire C. and Mosdzianowski C. ( 2001 ) New automation of 18 F-MPPF using a coincidence synthesizer . J. Labelled Cpd. ...
Preliminary studies using the microPET with anesthetized rats showed high [18F]MPPF binding in the hippocampus (Plénevaux et al., 2000b). In this same study, transverse PET images of the Vervet monkey also revealed the presence of [18F]MPPF binding in the NRD. Show abstract Development and...
The aim of this study was to determine if the brain uptake of 4-(2'-methoxyphenyl)-1-(2'-(N-2''-pyridinyl)-p-(18F)fluorobenzamido)ethy lpiperazine ((18F)MPPF), a radioligand for the imaging of 5-HT1A receptors, is influenced by the action of P-glycoprotein. Anesthetized male Wistar...
Effect of fenfluramine-induced increases in serotonin release on [18F]MPPF binding: a continuous infusion PET study in conscious monkeys. Synapse 2006;59:18-26. [PubMed: 16237679]Udo de Haes JI, Harada N, Elsinga PH, Maguire RP, Tsukada H (2006) Effect of fenfluramine-induced increases ...
Discrepancies in the P-glycoprotein-mediated transport of (18)F-MPPF: a phar- macokinetic study in mice and non-human primates. Pharm Res 2012;29(9): 2468-76.Tournier N, Cisternino S, Peyronneau MA, et al. Discrepancies in the P-glycoprotein- mediated transport of 18F-MPPF: a ...
2010. Uptake and binding of the serotonin 5-HT1A antagonist 18F-MPPF in brain of rats: effects of the novel P-glycoprotein inhibi- tor tariquidar. Neuroimage 49:1406-1415.LA FOUGERE C., BONING G., BARTMANN H., WANGLER B., NOWAK S., JUST T., WAGNER E., WINTER P., ROMINGER A.,...
Thereby, body weight development correlated with [18F]MPPF binding.Mild-to-moderate stress associated with daily transport and exposure to a laboratory environment can trigger significant alterations in hippocampal binding of the 5-HT1A receptor ligand [18F]MPPF. This finding indicates that utmost care...