恒河猴全身显像示肾、脾、肝和睾丸存在高摄取。Oga∆Br小鼠中18F-LSN3316612脑摄取较对照组降低82%,而周围器官摄取未受影响,与仅脑组织中表达OGA一致。估算18F-LSN3316612在人体的有效剂量为22 µSv/MBq,是典型的18F标记药物的剂量...
Methods: Ten healthy human volunteers underwent both test and retest PET scans using 18F-LSN3316612. Kinetic analysis was performed at the region level with 2TCM using 120-minute PET data, and arterial input function was used as the gold standard. Quantification was then obtained at both the ...
Demographic characteristics and PET scan parameters for 17 healthy volunteers injected with [ F]LSN3316612doi:10.1186/s13550-020-0616-4Jae-Hoon LeeJeih-San LiowSoumen PaulCheryl L. MorseMohammad B. HaskaliLester ManlySergey ShcherbininJ. Craig Ruble...
[18F]LSN3316612Parametric imageBackground Previous studies found that the positron emission tomography (PET) radioligand [ F]LSN3316612 accurately quantified O -GlcNAcase in human brain using a two-tissue compartment model (2TCM). This study sought to assess kinetic model(s) as an alternative to ...