Dynamic [18F]FSPG PET: impact of glutamate transport and glutaminase inhibition on redox imbalance and cell death in glutamine-dependent triple negative breast cancer1240Objectives: Upregulated glutamine metabolism is an important metabolic signature for aggressive and treatment resistant cancers, including ...
Results: Overall 18F- Fluoroglutamine PET showed sensitivity of 94% [CI 72.4-99.9%] and specificity of 67% [CI 9.5-99.2%] in differentiating true tumor progression from treatment related changes (TP=16; FP=1;TN=2;FN=1). On ROC curve analysis, SUV max, and TBPmax at 90 and 180 min...
Purpose There is a need for an alternative PET probe, which does not show normal brain tissue uptake in the evaluation of metastasis to the brain. Therefore, we investigate the feasibility of F-18-labeled glutamine analog, F-18-(2S,4R)-4-fluoroglutamine (F-18-FGln), as a new ...
本发明的18F(2S,4R)4氟L谷胺酰胺的自动化制备方法及其装置,使得自动化制备18F(2S,4R)4氟L谷胺酰胺得以实现,有利于提高制备的效率和稳定性,同时可以保护操作人员避免辐射损伤,为新型代谢显像剂18F(2S,4R)4氟L谷胺酰胺的临床应用奠定了基础. 18F- (2S, 4R) -4-fluoro invention -L- glutamine automated ...
BELOKON YURIKUZNETSOVA OLGA FEDOROVNAGRAHAM KEITHLEHMANN LUTZBERNDT MATHIASDinkelborg L,Friebe M,Krasikowa RN. labelled L-glutamic acid,[18F]labelled glutamine,their derivatives,their use and processes for their preparation[P].EP,1923382 2008.
Relating to compounds derived from l-glutamic acid marked with [18F] and l-glutamine marked with [18F] of formula (i), where a is Oh, NH2, N (alquiloc1 - C5) 2, among others; g is Oh, o-alkyl (C1 - C5) branched or unbranched, - alquinilo (C2 or C5) branched or unbranched...
(P= 0.002).#Although we do not assert that18F-FGln PET/CT imaging is satisfactory in the differential diagnosis of glioma, we revealed its potential for identifying the stage of gliomas and the IDH mutation status and propose that glutamine-based PET imaging enables the assessment of metabolic...
The development of radiolabeled glutamine derivatives could be a useful molecular imaging tool for visualizing these tumors. We elaborated on the glutamine-derived PET tracers by developing two novel probes, namely [F]fluorophenylglutamine and [F]fluorobiphenylglutamine. Materials and methods Both tracers...
We have firstly synthesized enantiopure (2S,4R)-4-fluoroglutamine (4-FGln) and validated it as a Gln transport analogue in human MM cell lines, comparing its uptake with that of 3H-labelled Gln. We then radiosynthesized of [18F]4-FGln and tested its uptake for MM detection by PET in...
Based on the fact that major inflammatory cells are heavily dependent on glutamine metabolism like cancer cells, we explored the potential utility of [18F]FGln as a metabolic imaging marker for inflammation in two rat models: carrageenan-induced paw edema (CIPE) and collagen-induced arthritis (...