18F-GE180分子探针|分子靶点:TSPO 中文名称:18F-GE180 介绍:18F-GE-180是转运蛋白(TSPO)的配体。 纯度:95%+ 储藏条件:-20°C下避光保存 用途:科研 状态:固体/粉末/溶液 分子式 核素概念是为了确切描述元素的原子量而引入的。化学原子概念是元素原子,即同一种元素对应有同一种原子,因此某种元素的原子量被规定...
18F-GE-180TSPOGliomaGradingMolecular geneticsBackground The 18-kDa translocator protein (TSPO) is overexpressed in brain tumours and represents an interesting target for glioma imaging. F-GE-180, a novel TSPO ligand, has shown improved binding affinity and a high target-to-background contrast in ...
The translocator protein (TSPO) is overexpressed in high-grade glioma and can be visualized in vivo by TSPO PET even in areas without MRI contrast enhancement. Here, we assessed the value of TSPO PET using the high-affinity TSPO ligand 18F-GE-180 in primary irradiation (RT) and re-irradiati...
18F-GE-180: a novel TSPO radiotracer compared to11C-R-PK11195 in a preclinical model of stroke18F-GE-180: a novel TSPO radiotracer compared to11C-R-PK11195 in a preclinical model of strokedoi:10.1007/s00259-014-2939-8Positron emission tomographyTranslocator...
Giuseppe PasqualettiImperial College LondonLondonUnited KingdomWilliam TriggGE HealthcareAmershamUnited KingdomChris J. BuckleyGE HealthcareAmershamUnited KingdomFederico TurkheimerKings College LondonLondonUnited KingdomSteve GentlemanImperial College LondonLondonUnited KingdomRainer Hinz...
GE-180Purpose Neuroinflammation plays a critical role in various neuropathological conditions, and hence there is renewed interest in the translocator protein (TSPO) as a biomarker of microglial activation and macrophage infiltration in the brain. This is reflected in the large amount of research ...
Patients with higher [18F]GE-180-PET whole-brain load showed slower clinical progression. Concerning plasma biomarker NfL, higher plasma-NfL was prognostic of faster clinical deterioration. In a subsequent sensitivity analysis, we found that tau-PET, microglia-PET as well as plas...
[18F]GE-180Routine ProductionORA NeptisThe aim of this work is to develop a method to produce [~(18)F]GE-180 on a Neptis Perform Synthesizer? module with high radiochemical yield, purity and reproducibility. Herein is described the labelling, HPLC purification and final product formulation. ...
Conclusions: The distribution characteristics of [18F]GE-180 in the brain has demonstrated the potential of this tracer as a marker of neuroinflammation that may be relevant for tracking CCM disease progression and evaluating the effectiveness of potential drug therapies in future clinical trials.Sally...
F-18-GE-180 PETglioblastomacerebrospinal fluidTSPO imagingPET targeting the translocator protein (TSPO) represents an interesting approach for glioma visualization, as TSPO is highly expressed in tumor cells. We present a 32-year-old man with recurrent glioblastoma after multimodal treatment. PET with...