18F-GE180分子探针|分子靶点:TSPO 中文名称:18F-GE180 介绍:18F-GE-180是转运蛋白(TSPO)的配体。 纯度:95%+ 储藏条件:-20°C下避光保存 用途:科研 状态:固体/粉末/溶液 分子式 核素概念是为了确切描述元素的原子量而引入的。化学原子概念是元素原子,即同一种元素对应有同一种原子,因此某种元素的原子量被规定...
18F-GE-180TSPOGliomaGradingMolecular geneticsBackground The 18-kDa translocator protein (TSPO) is overexpressed in brain tumours and represents an interesting target for glioma imaging. F-GE-180, a novel TSPO ligand, has shown improved binding affinity and a high target-to-background contrast in ...
The translocator protein (TSPO) is overexpressed in high-grade glioma and can be visualized in vivo by TSPO PET even in areas without MRI contrast enhancement. Here, we assessed the value of TSPO PET using the high-affinity TSPO ligand 18F-GE-180 in primary irradiation (RT) and re-irradiati...
18F-GE-180: a novel TSPO radiotracer compared to11C-R-PK11195 in a preclinical model of strokedoi:10.1007/s00259-014-2939-8Positron emission tomographyTranslocator proteinR-PK11195Brain ischaemiaGE-180Neuroinflammation plays a critical role in various neuropathological conditions, and hence there ...
Grazia Daniela FemminellaImperial College LondonLondonUnited KingdomGiuseppe PasqualettiImperial College LondonLondonUnited KingdomWilliam TriggGE HealthcareAmershamUnited KingdomChris J. BuckleyGE HealthcareAmershamUnited KingdomFederico TurkheimerKings College LondonLondonUnited KingdomSteve Gentleman...
18F-GE-180是转运蛋白(TSPO)的配体。 详情介绍 18F-GE180分子探针|分子靶点:TSPO 中文名称:18F-GE180 介绍:18F-GE-180是转运蛋白(TSPO)的配体。 纯度:95%+ 储藏条件:-20°C下避光保存 用途:科研 状态:固体/粉末/溶液 分子式 核素概念是为了确切描述元素的原子量而引入的。化学原子概念是元素原子,即同一...
GE-180Purpose Neuroinflammation plays a critical role in various neuropathological conditions, and hence there is renewed interest in the translocator protein (TSPO) as a biomarker of microglial activation and macrophage infiltration in the brain. This is reflected in the large amount of research ...
Patients with higher [18F]GE-180-PET whole-brain load showed slower clinical progression. Concerning plasma biomarker NfL, higher plasma-NfL was prognostic of faster clinical deterioration. In a subsequent sensitivity analysis, we found that tau-PET, microglia-PET as well as plas...
[18F]GE-180Routine ProductionORA NeptisThe aim of this work is to develop a method to produce [~(18)F]GE-180 on a Neptis Perform Synthesizer? module with high radiochemical yield, purity and reproducibility. Herein is described the labelling, HPLC purification and final product formulation. ...
Conclusions: The distribution characteristics of [18F]GE-180 in the brain has demonstrated the potential of this tracer as a marker of neuroinflammation that may be relevant for tracking CCM disease progression and evaluating the effectiveness of potential drug therapies in future clinical trials.Sally...