多功能模块合成心肌显像剂18F-FTHA及Micro-PET显像
应用microPET/CT进行18F-FTHA和18F-FDG显像可以活体评价小鼠心肌脂肪酸和葡萄糖利用情况.在禁食或联合肝素的条件下,心肌代谢底物以脂肪酸为主;而在不禁食的条件下,心肌代谢底物以葡萄糖为主.因此,对于不同疾病小鼠模型下,定量判断小鼠心肌代谢改变情况,如若判断葡萄糖变化无需禁食,而判断脂肪酸改变情况,需要长时间...
Experimental Production and Initial Imaging of [18F]-14-Fluoro-6-thia-heptadecanoic acid ([18F]-FTHA) for Myocardial Performancediffraction tomographyimagingtexturetwo-dimensional polymerized C60disordered graphitecarbonIntroduction: [F]-6-thia-14-fluoro-heptadecanoic acid 3b, a free fatty acid, has ...
正常昆明小鼠体内生物学分布实验结果显示,18F-FTHA在血液中清除快,心肌摄取高,非靶器官摄取较低.在注射显像剂后60min时,心肌,肺和肝脏的放射性摄取分别为(19.04±4.87)%ID/g,(3.05±0.52)%ID/g和(5.99±2.96)%ID/g,心肌与肺的摄取比值为6/1(t=0.27,P=0.01),心肌与肝脏的摄取比值为3/1(t=0...
Thus, there is a need for accurate chromatographic methods to analyze the unmetabolized [18F]FTHA (parent fraction). Here we present a new radiometabolite analysis (RMA) method, with comparison to a previous method for parent fraction analysis, and its use in a test-retest clinical study ...
Experimental production and preliminary imaging of [18F]-6-thia-14-fluoro-heptadecanoic acid ([18F]FTHA) for myocardium evaluationProductionMyocardiumEvaluationPET Imaging[18F]-6-thia-14-fluoro-heptadecanoic acid 3b, a free fatty acid, has been used in mycardial PET imaging. In order to establish...
The radiolabeled long-chain fatty acid analog, 14( R, S)-[ 18F]fluoro-6-thia-heptadecanoic acid (FTHA), was designed (DeGrado, 1991) to undergo metabolic trapping subsequent to its commitment to the beta-oxidation (beta-ox) pathway. FTHA was evaluated under various conditions in two ...
Schulz G, von Dahl J, Kaiser HJ, et al. Imaging of β-oxidation by static PET with 14(R,S)-[18F]-fluoro-6-thiaheptadecanoic acid (FTHA) in patients with advanced coronary heart disease: a comparison with 18FDG-PET and 99mTc-MIBI SPET. Nucl Med Commun 1996;17:1057–...
正常昆明小鼠体内生物学分布实验结果显示,18F-FTHA在血液中清除快,心肌摄取高,非靶器官摄取较低.在注射显像剂后60 min时,心肌,肺和肝脏的放射性摄取分别为(19.04±4.87)%ID/g,(3.05±0.52) %ID/g和(5.99±2.96) %ID/g,心肌与肺的摄取比值为6/1(t=0.27,P=0.01),心肌与肝脏的摄取比值为3/...
Biodistribution of the fatty acid analogue 18F- FTHA: plasma and tissue partitioning between lipid pools during fasting and hyperinsulinemia. J Nucl Med 48: 455- 462, 2007.L. Guiducci, T. Gronroos, M.J. Jarvisalo, et al., Biodistribution of the fatty acid analogue 18F-FTHA: plasma and ...