这项研究的意义在于:首次系统验证了商业软件校正即时背靠背扫描的可行性,使18 F-flurpiridaz的半衰期优势转化为临床效率提升。未来推广该技术可望实现三大突破:将患者检查时间缩短70%、提高设备周转率、改善静息-负荷图像配准精度,为CAD诊断建立新的"黄金标准"流程。
PET MPIPET tracersCoronary artery disease (CAD) is the most common form of heart disease and remains the leading cause of death for men and women in the U.S., with 680,909 deaths recorded in 2023 [1]. Myocardial perfusion imaging (MPI) is one of the most used imaging methods for non...
2020, 44(3): 151-155. 18F-Flurpiridaz的制备及其在正常巴马小型猪PET/CT心肌灌注显像中的初步实验研究 . 本文全文图片 18F-Flurpiridaz的合成路线图 正常巴马小型猪的18F-Flurpiridaz与13N-NH3·H2O PET/CT MPI图 正常巴马小型猪18F-Flurpiridaz PET/CT全身显像图...
This concept pertains also to 18F-flurpiridaz PET. If its predictive value will be higher than that of other noninvasive modalities, we will be able to speak of a new era.References 1 J. Maddahi, D. Agostini, T.M. Bateman, et al. Flurpiridaz F-18 PET myocardial perfusion imaging in...
目的 探讨合成18F-Flurpiridaz的优化方法,评估其在正常巴马小型猪PET/CT心肌灌注显像(MPI)中的分布情况。 方法 以18F取代2-叔丁基-4-氯-5-[4-(2-甲基磺酰基-乙氧基甲基)苯基甲氧基]哒嗪-3-哒嗪酮中的苯磺酸离去基团进行标记,通过高效液相色谱非梯度洗脱的方法纯化产物。5头正常巴马小型猪经耳缘静脉注射37...
18F-Flurpiridazdoi:10.1007/978-3-031-10271-4_36Flurpiridaz is used for myocardial perfusion imaging at rest and stress for diagnosis of coronary artery disease.Ballinger, James R.
Background/Introduction 18F-flurpiridaz, a novel positron emission tomography (PET) myocardial perfusion (MPI) imaging tracer, has shown efficacy in the detection of obstructive coronary artery disease (CAD) and is anticipated to be adopted in clinical practice soon. This post-hoc analysis of the...
A two-injection, single-scan protocol was used in which an adenosine infusion was started 4minutes after the first injection of18F-Flurpiridaz and followed either 3 or 6minutes later by a second radiotracer injection. In two pigs, microsphere flow measurements were made at rest and during ...
的研制开创了正电子血流灌注显像剂的新领域.18F-Flurpiridaz的临床前期和临床试验的初步结果显示其具有理想PET MPI显像剂的重要特性,即心肌摄取率高,对图像的灌注缺损判别分辨率高,心肌清除速度慢,随着时间的推移靶/非靶比值稳定,并能定量分析血流,具有较佳的临床应用前景.该文介绍了18F-Flurpiridaz PET MPI的研究...
目的探讨合成18F-Flurpiridaz的优化方法,评估其在正常巴马小型猪PET/CT心肌灌注显像(MPI)中的分布情况.方法以18F取代2-叔丁基-4-氯-5-[4-(2-甲基磺酰基-乙氧基甲基)苯基甲氧基]哒嗪-3-哒嗪酮中的苯磺酸离去基团进行标记,通过高效液相色谱非梯度洗脱的方法纯化产物.5头正常巴马小型猪经耳缘...