正常大鼠小动物PET显像图中sT显影清晰(ST/CB=2.18±0.16,n=3),双侧对称;PD模型大鼠未损毁侧sT放射性浓聚(ST未损毁侧/CB=2.01±0.23,n=3),而损毁侧ST放射性摄取不明显,与小脑相当(ST损毁侧/CB=1.04±0.05).结论 18F-FECNT能透过无损的血脑屏障浓聚于ST,对DAT具有高亲和性与特异性,是一种有临床应用潜力...
A one-step fully automated radio-synthesis of a dopamine transporter PET imaging agent 18F-FECNT and its in vivo evaluationsPractical, Experimental/ biomedical imagingdiseasespositron emission tomographyradiation therapyradiochemistry/ Parkinsons disease model rats...
Then, [18F]FECNT-d4 was synthesized from the deuterated precursor with an average activity yield of 46卤17% (n = 15) and the molar activity > 55 GBq/渭mol. This deuterated tracer showed suitable lipophilicity and the ability to penetrate the blood-brain barrier (brain uptake of 1.75 %ID...
18F-2beta-Carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane (18F-FECNT), a PET radioligand for the dopamine transporter (DAT), generates a radiometabolite that enters the rat brain. The aims of this study were to characterize this radiometabolite and to determine whether a ...
A one-step automated high-radiochemical-yield synthesis of 18F-FECNT from mesylate precursor[J]. Appl Radiat Isotopes,2008,66:1881-1885.A one-step automated high-radiochemical-yield synthesis of 18 F-FECNT from mesylate precursor[J] . Zheng Ping Chen,Song Pei Wang,Xiao Min Li,Chun Yi ...
Davis Margaret R,Votaw John R,Bremner J Douglas,Byas-Smith Michael G,Faber Tracy L,Voll Ronald J,Hoffman John M,Grafton Scott T,Kilts Clinton D,Goodman Mark M.Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT.Journal of nuclear medicine : official publication, ...
18FDeuteriumIn vivostabilityThe dopamine transporter (DAT) is a marker of the occurrence and development of Parkinson's disease (PD) and other diseases with nigrostriatal degeneration. 2尾-Carbomethoxy-3尾-(4-chlorophenyl)-8-(2-[18F]-fluoroethyl)nortropane ([18F]FECNT), an18F-labelled tropane...
Introduction The clinically established positron emission tomography (PET) tracers 6-[18F]-fluoro-l-DOPA ([18F]FDOPA), 6-[18F]-fluoro-l-m-tyrosine ([18F]FMT) and 2尾-carbomethoxy-3尾-(4-chlorophenyl)-8-(2-[18F]-fluoroethyl)-nortropane ([18F]FECNT) serve as markers of presynaptic ...
Herein, the automated synthesis of [18F]FECNT from its chlorinated precursor in commercially available SynChrom [18F] R&D module has been developed. The synthesis unit was readily configured for the one-step synthesis from corresponding chlorinated precursor. The radiolabeling process involved a ...
2004. Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine transporter probe 18F-FECNT in non-human primates. Nucl Med Commun 25(7):737-742.Tipre DN, Fujita M, Chin FT, et al. Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine ...