本申请要求2014年11月25日提交的标题为“用于生物制品的18f-放射性标记的方法和组合物”的美国临时申请62/084,366的优先权,其内容通过引用由此并入。 本发明涉及18f-辅基(prostheticgroup),以及18f-标记的组合物的合成以及用于对体内各种过程成像、用于检测与疾病病理学相关的分子定位和用于监测疾病进展的用途。 背景技...
The inclusion criteria were the following: (1) pathologically proven locally advanced or metastatic NSCLC; (2) an indication to start immune checkpoint inhibitors in first or later line; (3) performance status on the East...
(1)收集临床数据:性别、年龄、血清乳酸脱氢酶(lactatedehydrogenase, LDH)水平、原发灶部位(肢端型和非肢端型)、TNM分期、患者东方合作肿瘤学组(Eastern Cooperative Oncology Group, ECOG)评分、前哨淋巴结(sentinel lymph node, SLN)状态...
【简介】葡萄糖是人体代谢能源物质之一,恶性肿瘤细胞代谢旺盛,对葡萄糖的代谢远超过正常细胞,将核素氟[ 18F ]标记到脱氧糖上(DG) ,其性质与葡萄糖基本一致参与细胞代谢。使用PET-CT捕捉人体组织的 18F-FDG糖代谢 ,可探测肿瘤细胞活跃程度,因此被誉为“二十一世纪分子”。
The detection rates for lymph node metastasis lesions were 10/15 in the G2/G15 groups, which were higher than the detection rate in the C PET/CT group (64.4%(29/45); χ2=62.03, P=0.002). Conclusion One-tenth dose 18F-FDG TB PET/CT with a 2-minute acquisition is feasibility in...
图2:通过辅基(prostheticgroup)的18f-氟化 图3:用于肽的18f-辅基 图4:使用“点击化学”的18f-标记的辅基 图5:[18f]芳基三氟硼酸酯和氟化物传感器的形成 图6:18f-氟化物的络合物 图7:rgd肽的18f-标记 图8:[18f]psma-1007在psma-阳性lncap小鼠(正常的和阻断的)和在psma阴性pc3小鼠中以及[18f]psma-1009([...
every 3 weeks. Random allocation was stratified by hormone receptor status. Centrally reviewed PET was conducted at baseline and after two treatment cycles. Patients in group B were treated according to on-treatment PET results. Patients in group B who were PET-responders continued with trastuzumab...
[2]Llombart-Cussac, A., et al., HER2-enriched subtype as a predictor of pathological complete response following trastuzumab and lapatinib without chemotherapy in early-stage HER2-positive breast cancer (PAMELA): an open-label, single-group, multicentre, phase 2 trial. Lancet Oncol, 2017. 18(...
近日,东诚药业集团控股子公司烟台蓝纳成生物技术有限公司(以下简称“蓝纳成”)收到北京医院伦理委员会出具的关于氟[18F]思睿肽注射液 III 期临床试验的伦理审查意见,氟[18F]思睿肽注射液正式开展 III 期临床试验。 2022年7月,蓝纳成收到国家药品监督管理局核准签发关于氟[18F]思睿肽注射液的《药物临床试验批准通...
In both well-differentiated and poorly differentiated group, 68Ga-DOTATATE PET/CT did not significantly differ from 18F-FDG PET/CT in identifying primary and distant lesions. In all patients with GEP-NEN in this study, 68Ga-DOTATATE PET/CT were positive in 77.5% (55/71)patients, 18F-FDG ...