中硼医疗研究人员表示，18F-BPA是BPA的成对诊断药物，二者在人体内生物学特性基本相似，由于18F核素发射的射线能够被PET/CT探测到，并形成影像，因此临床使用18F-BPA PET/CT图像在BNCT治疗前观察体内药物摄取情况，可用于患者筛选、治疗计划制定，并且在BNCT后可用于进行随访监测。相较于MRI存在因炎性坏死等引起的影像...
研究人员指出，18F-BPA是BPA的成对诊断药物，二者在人体内生物学特性相似，因其能够发射的射线被PET/CT探测到形成影像，故临床使用18F-BPA PET/CT图像在BNCT治疗前观察体内药物摄取情况，可用于患者筛选、治疗计划制定，并在BNCT后用于进行随访监测。相较于MRI存在的影像假性进展问题，FDG-PET技术因糖代谢...
中硼医疗研究人员表示,18F-BPA是BPA的成对诊断药物,二者在人体内生物学特性基本相似,由于18F核素发射的射线能够被PET/CT探测到,并形成影像,因此临床使用18F-BPA PET/CT图像在BNCT治疗前观察体内药物摄取情况,可用于患者筛选、治疗计划制定,并且在BNCT后可用于进行随访监测。 相较于MRI存在因炎性坏死等引起的影像假性...
18F-BPA PETradiation absorbed doseeffective doseBackground: Boron neutron capture therapy (BNCT) is a molecular radiation therapy approach based on the B-10 (n, alpha) 7 Li nuclear reaction in cancer cells. In BNCT, delivery of B-10 in the form of 4-borono-phenylalanine conjugated with ...
This study is a single-arm, single-center trial aimed at evaluating the pharmacokinetics, bio-distribution, dosimetry, and safety of 18F-LNC1007 injection in healthy volunteers and light tumor burden cancer patients, as defined by <5 lesions on a conventional PET/CT done for clinical purposes an...
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小鼠模型显示[18F]FBPA在肿瘤组织富集,且与治疗用L-BPA药代动力学高度一致,验证其作为替代标志物的可靠性。 2.临床转化优势: 精准剂量预测:通过PET成像计算的肿瘤/正常组织(T/N)比>2时,临床疗效显著。 治疗诊断一体化:结合FBPA-PET与BNCT,可动态调整硼给药方案,减少正常组织毒性。
As a diagnosing agent, the T/N radioactivity ratio is a decisive index, and FBY has shown to be a promising PET imaging agent for diagnosing tumors. For use as a therapeutic agent against tumors, boron concentrations must be as high as possible. In comparison with its high tumoral ...
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Methods: A cohort study was performed on patients who underwent BPA-PET between February 2017 and April 2022 in our hospital. Patients were stratified into two groups: those subjected to BNCT (Group 1) and those not (Group 2). The tumor to normal tissue (T/N) ratio derived from BPA-PET...