Methods: In vitro binding assays with 18F-BMS-986192 were performed on human tumor cell lines with different total cellular and membrane PD-L1 protein expression levels. Subsequently, PET imaging was performed on immunodeficient mice xenografted with these cell lines. The mice were treated with ...
18F-BMS986192 PET imaging of PD-L1 in metastatic melanoma patients with brain metastases treated with immune checkpoint inhibitors: a pilot study. J Nucl Med. 2021. https://doi.org/10.2967/jnumed.121.262368. PubMed Google Scholar De Silva RA, Kumar D, Lisok A, Chatterjee S, Wharram B,...
18F-BMS-986192曾在非小细胞肺癌和黑色素瘤中进行过评估,它与病理评估和治疗响应之间的相关性通过这种方法得到了证实,但它的合成具有挑战性,并且只能以低放射化学产率分离出来。18F-BMS-986229 是一种大环肽,与 PD-L1 有很高的亲和力,与受体结合紧密,脱靶速度慢,能迅速从非 PD-L1 表达组织中清除,能以更高的产...
18F-BMS-986192 bound to tumor tissues as a function of PD-L1 expression determined by immunohistochemistry. Radioligand binding was blocked in a dose-dependent manner. In vivo PET imaging clearly visualized PD-L1 expression in mice implanted with PD-L1(+), L2987 xenograft tumors. Two hours ...
18F-BMS-986229 是一种大环肽,与 PD-L1 有很高的亲和力,与受体结合紧密,脱靶速度慢,能迅速从非 PD-L1 表达组织中清除,能以更高的产量分离出来,同时合成难度也低于 18F-BMS-986192。18F-BMS-986229 的临床前评估表明,它能在体外和体内与表达 PD-L1 的组织特异性结合。本研究是首次针对 GEC患者进行的PD-L1...