Biosynthesis of 18(R)-hydroxyeicosatetraenoic acid from arachidonic acid by microsomes of monkey seminal vesicles. J. Biol. Chem. 264, 17845±17853.Oliw, E.H. (1989) Biosynthesis of 18( R )-Hydroxyeicosatetraenoic Acid from Arachidonic Acid by Microsomes of Monkey Seminal Vesicles, J. Biol....
12(R)-hydroxyeicosatetraenoic acid [12(R)-HETE] is present in large quantities in human psoriatic lesional skin and can be further metabolized by 5-LO to 5(S), 12(R)-dihydroxy-(6E,8Z,10E,14Z)-eicosatetraenoic acid...doi:10.1016/0014-2999(90)92390-5T.S. Gaginella...
Eicosapentaenoic acidTotal synthesisConvergent strategyReductionThe four stereoisomers of novel lipid mediator 1, (5Z,8Z,10E,14Z)-12-hydroxy-17,18-epoxy-5,8,10,14-eicosatetraenoic acid, were synthesized from six simple fragments. Triyne 2 was convergently assembled through three S(N)2 ...
The four stereoisomers of novel lipid mediator1, (5Z,8Z,10E,14Z)-12-hydroxy-17,18-epoxy-5,8,10,14-eicosatetraenoic acid, were synthesized from six simple fragments. Triyne2was convergently assembled through three SN2 alkynylation reactions and one Sonogashira coupling reaction. Two of the ...