Morin C,Sirois M,EchavéV,et al.17,18-epoxyeicosatetraenoic acid targets PPARγand p38mitogen-activated protein kinase to mediate its anti-inflammatory effect in lung:role of soluble epoxide hydrolase.Am J Respir Cell Mol Biol. 2009Morin C,Sirois M,EchavéV,et al.1...
17,18-Epoxyeicosatetraenoic acid G protein–coupled receptor 40 ω3 fatty acid contact hypersensitivity dermatitis neutrophil Abbreviations used ALA α-Linolenic acid APC Allophycocyanin Chi3l3 Chitinase 3–like 3 CYP Cytochrome P450 DAPI 4′-6-Diamidino-2-phenylindole dihydrochloride DC Dendritic cell DN...
(±)17(18)-EpETE详情 评价(0) 货号: ajcx20834 CAS: N/A 别名: (±)17,18-EEQ, (±)17,18-epoxy Eicosatetraenoic Acid 分子式: C20H30O3 分子量: 318.5 纯度: >98% 溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml 储存: Store at...
ω3 polyunsaturated fatty acids (PUFAs) have anti-allergic and anti-inflammatory properties, but the immune-metabolic progression from dietary oil remains to be investigated. Here we identified 17,18-epoxyeicostetraenoic acid (17,18-EpETE) as an anti-all
Dietary v3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut Jun Kunisawa1,2,3,4,5,6,7,8*, Makoto Arita9,10,11,12*, Takahiro Hayasaka13, Takashi Harada13, Ryo Iwamoto11, Risa Nagasawa1,2, Shiori Shikata1,2, Takahiro Nagatake...
Among EPA-derived metabolites, 12-hydroxy-17,18-epoxyeicosatetraenoic acid (12-OH-17,18-EpETE) was identified as one of the major biosynthesized molecules; the production of this molecule was amplified by EPA administration and allergic inflammation. Intravenous administration of 12-OH-17,18-E...
Dietary intake of ω3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid is beneficial for health control. We recently identified 17,18‐epoxyeicosatetraenoic acid (17,18‐EpETE) as a lipid metabolite endogenously generated from eicosapentaenoic acid that exhibits potent ...
Arachidonic acid, an omega-6 fatty acid, is metabolized into cysteinyl leukotriene with pro-inflammatory properties for allergic inflammation, whereas the omega-3 fatty acid eicosapentaenoic acid (EPA) and its downstream metabolites are known to have anti-inflammatory effects. In this study, we ...
This study was aimed to investigate the role of eicosapentaenoic acid monoacylglyceride (MAG-EPA) and 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) on the regulation of contractile reactivity and nuclear protein expression in 72-h-cultured and TNF-α-treated guinea pig tracheal rings. Tension ...
The four stereoisomers of novel lipid mediator1, (5Z,8Z,10E,14Z)-12-hydroxy-17,18-epoxy-5,8,10,14-eicosatetraenoic acid, were synthesized from six simple fragments. Triyne2was convergently assembled through three SN2 alkynylation reactions and one Sonogashira coupling reaction. Two of the ...