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We saw that 15-keto-PGE2 have anti-inflammatory effects in LPS-stimulated RAW 264.7 cells by inhibiting the NF-κB inflammatory pathway. The treatment of 15-keto-PGE2 led to a reduction of the pro-inflammatory cytokine expressions and Igκ-mediated reporter activities. 15-keto-PGE2 further ...
13,14-dihydro-15-keto前列腺素E2(13,14-dihydro-15-keto PGE2)是由15-羟基PGDH和15-oxo-PGδ13-还原酶生物合成的PGE2的代谢产物。该化合物积累到可检测的水平,然后进行进一步的代谢和化学分解,使其半衰期相对较短(〜9分钟),但比PGE2更长(〜2分钟),因此该化合物的累积量可观PGE2表达过程中的水平。受体结...
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The time-dependent release of prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha), thromboxane (Tx) B2, and 6-keto-PGF1 alpha (6-keto) from brain was measured before, during, and after a 15-min interval of total ischemia (four-vessel occlusion) in halothane-anesthetized cats usin...
炎症胰岛素抵抗磷酸化胰岛素受体底物目的探讨前列腺素家族(prostaglandins,PGs)成员对非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)的影响.方法以人肝癌细胞系HepG2细胞为研究对象.试验设为对照组(Ctrl),脂肪变组(FFA),前列腺素B2(PGB2,10μg/mL)处理组,15-酮基-前列腺素E2(15...
Levine, L (1977) Levels of 13,14-dihydro-15-keto-PGE2 in some biological fluids as measured by radioimmunoassay. Prostaglandins 14: pp. 1125Levine L. Levels of 13, 14-dihydro-15-Keto-PGE2 in some biological fluids as measured by radio-immunoassay. Prost- aglandins 1977; 14: 1125-39....
(2013) 15-hydroxyprostaglandin dehydrogenase (15-PGDH)-derived 15-keto-PGE2 inhibits cholangiocarcinoma cell growth through interaction with PPARgamma, SMAD2/3 and TAP63. J Biol Chemhydroxyprostaglandin dehydrogenase (15-PGDH)-derived 15-keto-PGE2 inhibits cholangiocarcinoma cell gr...
The metabolite 13,14‐dihydro‐15‐keto‐PGE2 related to B. animalis F1‐7 is found, which has a potential improvement effect on OIC at 20mg kg BW1 in vivo. At 30ng mL1 it effectively stimulates secretion of CGA/5‐HT (408.95± 1.18ngmL1) by PC‐12 cells and chang...
Wu. 2014. 15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPAR gamma-mediated activation of p21WAF1/Cip1. Oncogene 33: 1101–12. CentralLu D, Han C, Wu T. 15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARγ- mediated activation of p21W...