Additionally, both mass spectrometry imaging (MSI) and targeted metabolomics analyses confirmed the significant increase in 15-HETE levels in mice with MI and in patients with MI and acute coronary syndrome (ACS). Our comprehensive dataset suggests that NLRP3 inflammasome activation in MI is ...
15-Lipoxygenase metabolites of α-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome Naresh Kumar, Geetika Gupta, Kotha Anilkumar, Naireen Fatima, Roy Karnati, Gorla Venkateswara Reddy, Priyanka Voori Giri & Pallu ...
13-(S)-HPOTrE and 13-(S)-HOTrE inactivate inflammasome in PPAR-γ dependent manner in RAW 264.7 cells and peritoneal macrophages. It is well known that NLRP3 inflammasome, an intra- cellular sensor that detects pathogens and sterile inflammation, gets activated in part through NF-κB...
(S)-HETE对骨细胞分化及其焦亡作用的影响2.1 15-LOX-2敲低骨细胞通过焦亡对骨细胞分化的作用及机制研究2.1.1下调15-LOX-2促进破骨细胞焦亡并加速破骨化进程破骨细胞TRAP染色后可见细胞胞质呈紫红色;WB结果显示:敲低组细胞中GSDMD和NLRP3蛋白水平明显高于对照组细胞;同样,敲低组细胞内GSDMD,IL-1α的m RNA水平...