aFor simplicity we use here and in all our other publications the term “NFAT factors” for members of a family of transcription factors which share a number of specific properties, e.g. the induction by calcineurin which de-phosphorylates an array of phosphorylated sites upon cell activation. ...
Administration of AG-1478 blocks phosphorylation of the EGFR at the tumor site and inhibits the growth of A431 xenografts that overexpress the WT EGFR and glioma xenografts expressing the de2-7 EGFR. Even subtherapeutic doses of AG-1478 significantly enhance the efficacy of cytotoxic drugs, with...
2006年毕业于中国协和医科大学,获得博士学位2010年至2013年在美国国立卫生研究院从事博士后工作主要从事白血病的基础和临床研究 诊断治疗不断优化,疗效提升“未来可期” 魏辉教授:AML领域的新进展主要聚焦于诊断和治疗两个方面。首先,在诊断方面...
体内研究AG-1478给药阻断肿瘤位点的EGFR磷酸化,并抑制过表达wt EGFR的A431异种移植物和表达de2-7 EGFR的胶质瘤异种移植物的生长。甚至不足治疗剂量的AG-1478也能够显著增强细胞毒性药物的效能,结合AG-1478和temozolomide对人胶质瘤异种移植物表现出协同的抗肿瘤活性。AG-1478结合抗-EGFR抗体(mAb 806)对过表达EGFR的...
This suggestion is supported by analyses of stomach contents fromstomachs contained high proportions ofin the first half of the year 2006. The disappearance ofin early summer and the comparatively low proportion of adults for most part of the investigation period also indicate that fish predation is...
Di Pasquale G, Salignon M, Le Conte Y, Belzunces LP, Decourtye A, Kretzschmar A et al. (2013). Influence of pollen nutrition on honey bee health: do pollen quality and diversity matter? PLoS One 8: e72016. Dolgin ES, Charlesworth B (2006). The fate of transposable elements in ...
Twigger K, Vidal L, White CL, De Bono JS, Bhide S, Coffey M et al. (2008). Enhanced in vitro and in vivo cytotoxicity of combined reovirus and radiotherapy. Clin Cancer Res 14: 912–923. Article CAS Google Scholar van Houdt WJ, Smakman N, van den Wollenberg DJ, Emmink BL, Vee...
Another example is an enzyme that dephosphorylates ERK, the phosphatase MKP3, which negatively regulates ERK activation [86]. MKP3 directly interacts with ERK through a region of the phosphatase termed kinase interaction motif (KIM). Interestingly, this interaction is independent of the phosphorylation...
2006, 52: 305-315. 10.1016/j.brainresrev.2006.04.005. Article CAS PubMed Google Scholar Nevrivy DJ, Peterson VJ, Avram D, Ishmael JE, Hansen SG, Dowell P, Hruby DE, Dawson MI, Leid M: Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of...
临沂大学制药工程专业面向山东省医药大省和临沂市制药大市的产业需求,始建于2005年,2006年开始招生,是山东省卓越工程师教育培养计划专业、山东省高水平应用型专业(群)立项建设专业、山东省一流本科专业建设点、国家一流本科专业建设点、工程教育认证通过专业、山东...