本发明公开了12oxoLTB4在制备抗心肌纤维化损伤药物中的应用.具体为,化合物12oxoLTB4能促进巨噬细胞对凋亡心肌成纤维细胞的吞噬,改善异丙肾上腺素所致小鼠心肌纤维化损伤.具体表现在:(1)在体外能促进RAW264.7巨噬细胞和BMDM巨噬细胞对荧光微球和凋亡心肌成纤维细胞的吞噬;(2)在体内能显著降低异丙肾上腺素诱导心肌纤维...
P. WHEELANClaude Pepper Inst.W. S. POWELLClaude Pepper Inst.ChemInformKhanapure SP, Manna S, Rokach J, Murphy RC, Wheelan P, Powell WS. 12-Oxo-LTB4, a key pivotal intermediate in LTB4 metabolism. J Org Chem 1995; 60: 1806-1813....
W. S. POWELLClaude Pepper Inst., Dep. Chem., Melbourne, FL 32901, USAJohn Wiley & Sons, Ltd.CheminformKhanapure SP, Manna S, Rokach J, Murphy RC, Wheelan P, Powell WS. 12-Oxo-LTB4, a key pivotal intermediate in LTB4 metabolism. J Org Chem 1995; 60: 1806-1813....
Describes the synthesis of 5(S)-hydroxy-12-oxo-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid (12-oxo-LTB4). Incubation of the synthetic 12-oxo-LTB4 with human keratinocytes; Comparison of the 12-oxo-LTB4 prepared from porcine leukocytes with the synthetic material; Formation of the 6-...